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    The N-terminus of vaccinia virus host range protein C7L is essential for function

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    Authors
    Terajima, Masanori
    Urban, Stina L.
    Leporati, Anita M.
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Department of Pathology
    Document Type
    Journal Article
    Publication Date
    2013-02-01
    Keywords
    DNA Mutational Analysis
    *Host Specificity
    Recombination, Genetic
    Vaccinia virus
    Viral Proteins
    Vaccinia virus
    Host range gene
    C7L
    Poxvirus
    Immunomodulatory gene
    Immunology and Infectious Disease
    Immunoprophylaxis and Therapy
    Medical Microbiology
    Molecular Genetics
    Virology
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    Link to Full Text
    http://dx.doi.org/10.1007/s11262-012-0822-x
    Abstract
    Vaccinia virus (VACV), a member of the Poxviridae family of large double-stranded DNA viruses, is being used as a smallpox vaccine as well as an expression vector for immunization against other infectious diseases and cancer. The host range of wild type VACV is very broad among mammalian cells. C7L is a host range gene identified in VACV and is well conserved in mammalian poxviruses except for parapoxviruses and molluscum contagiosum virus. The molecular mechanisms by which the C7L gene exerts host range function are not well understood. The C7L protein does not have any known conserved domains or show sequence similarity to cellular proteins or viral proteins other than the C7L homologs in mammalian poxviruses. We generated recombinant vaccinia viruses carrying deletion mutants of the C7L gene using NYVAC as a parental strain and found that the N-terminus is essential for host range function of C7L, which is consistent with a previous report that showed that homology among C7L homologs are greater near the N-terminus than the C-terminus.
    Source
    Virus Genes. 2013 Feb;46(1):20-7. doi: 10.1007/s11262-012-0822-x. Link to article on publisher's site
    DOI
    10.1007/s11262-012-0822-x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29800
    PubMed ID
    23001690
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11262-012-0822-x
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