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    The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and is Influenced by Medication Exposures, Age, Environment, and Frailty

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    Authors
    Haran, John P
    Zeamer, Abigail
    Ward, Doyle V.
    Dutta, Protiva
    Bucci, Vanni
    McCormick, Beth A.
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences
    Program in Microbiome Dynamics
    Department of Microbiology and Physiological Systems
    Department of Emergency Medicine
    Document Type
    Journal Article
    Publication Date
    2021-06-14
    Keywords
    Medications
    antibiotics
    frailty
    gut microbiome
    nursing home
    residents
    Digestive System
    Environmental Public Health
    Geriatrics
    Medical Microbiology
    Pathological Conditions, Signs and Symptoms
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    Link to Full Text
    https://doi.org/10.1093/gerona/glab167
    Abstract
    Older adults in nursing homes (NHs) have increased frailty, medication, and antimicrobial exposures, all factors that are known to affect the composition of gut microbiota. Our objective was to define which factors have the greatest association with the NH resident gut microbiota, explore patterns of dysbiosis and compositional changes in gut microbiota over time in this environment. We collected serial stool samples from NH residents. Residents were assessed using the Mini Nutritional Assessment tool and Clinical Frailty Scale. Bacterial composition of resident stool samples was determined by metagenomic sequencing. We used mixed-effect random forest modeling to identify clinical covariates that associate with microbiota. We enrolled and followed 166 residents from 5 NHs collecting 512 stool samples and following 15 residents for > 1 year. Medications, particularly psychoactive and anti-hypertensive medications, had the greatest effect on the microbiota. Age and frailty also contributed, and were associated with increased and decreased diversity, respectively. The microbiota of residents who had lived in the NH for > 1 year were enriched in inflammatory and pathogenic species and reduced in anti-inflammatory and symbiotic species. We observed intra-individual stability of the microbiome among older adults who had lived in the NH already for > 1 year followed with sample collections 1 year apart. Older adult NH gut microbiome is heavily influenced by medications, age, and frailty. This microbiome is influenced by length of NH residence with dysbiosis becoming evident at 12 months, however after this point there is demonstrated relative stability over time.
    Source

    Haran JP, Zeamer A, Ward DV, Dutta P, Bucci V, McCormick BA. The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and is Influenced by Medication Exposures, Age, Environment, and Frailty. J Gerontol A Biol Sci Med Sci. 2021 Jun 14:glab167. doi: 10.1093/gerona/glab167. Epub ahead of print. PMID: 34125200. Link to article on publisher's site

    DOI
    10.1093/gerona/glab167
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29847
    PubMed ID
    34125200
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1093/gerona/glab167
    Scopus Count
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    Morningside GSBS Scholarly Publications
    UMass Chan Faculty and Researcher Publications
    Emergency Medicine Publications

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