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dc.contributor.authorZhang, Ben
dc.contributor.authorSkelly, Jordan D.
dc.contributor.authorBraun, Benjamin M.
dc.contributor.authorAyers, David C.
dc.contributor.authorSong, Jie
dc.date2022-08-11T08:08:28.000
dc.date.accessioned2022-08-23T15:56:08Z
dc.date.available2022-08-23T15:56:08Z
dc.date.issued2021-09-02
dc.date.submitted2021-12-13
dc.identifier.citation<p>Zhang B, Skelly JD, Braun BM, Ayers DC, Song J. Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing <em>S. aureus</em> periprosthetic infections. ACS Appl Bio Mater. 2020 Sep 21;3(9):5896-5904. doi: 10.1021/acsabm.0c00600. Epub 2020 Sep 2. PMID: 34368642; PMCID: PMC8340630. <a href="https://doi.org/10.1021/acsabm.0c00600">Link to article on publisher's site</a></p>
dc.identifier.issn2576-6422 (Linking)
dc.identifier.doi10.1021/acsabm.0c00600
dc.identifier.pmid34368642
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29904
dc.description.abstractImplant-associated bacterial infections are difficult to treat due to the tendency of biofilm formation on implant surfaces, which protects embedded pathogens from host defense and impedes antibiotic penetration, rendering systemic antibiotic injections ineffective. Here, we test the hypothesis that implant coatings that reduce bacterial colonization would make planktonic bacteria within the periprosthetic environment more susceptible to conventional systemic antibiotic treatment. We covalently grafted zwitterionic polymer brushes poly(sulfobetaine methacryate) from Ti6Al4V surface to increase the substrate surface hydrophilicity and reduce staphylococcus aureus (S. aureus) adhesion. Using a mouse femoral intramedullary (IM) canal infection model, we showed that the anti-fouling coating applied to Ti6Al4V IM implants, when combined with a single vancomycin systemic injection, significantly suppressed both bacterial colonization on implant surfaces and the periprosthetic infections, outperforming either treatment alone. This work supports the hypothesis that grafting anti-fouling polymers to implant surfaces improves the efficacy of systemic antibiotic injections to combat periprosthetic infections.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34368642&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340630/
dc.subjectStaphylococcus aureus
dc.subjectanti-fouling
dc.subjectbacterial colonization on surfaces
dc.subjectosteomyelitis
dc.subjectperiprosthetic infections
dc.subjectplanktonic bacteria
dc.subjectzwitterionic polymer brush
dc.subjectBacterial Infections and Mycoses
dc.subjectBiomaterials
dc.subjectBiomedical Devices and Instrumentation
dc.subjectMaterials Chemistry
dc.subjectOrthopedics
dc.titleSurface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing S. aureus periprosthetic infections
dc.typeJournal Article
dc.source.journaltitleACS applied bio materials
dc.source.volume3
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/2108
dc.identifier.contextkey26821445
html.description.abstract<p>Implant-associated bacterial infections are difficult to treat due to the tendency of biofilm formation on implant surfaces, which protects embedded pathogens from host defense and impedes antibiotic penetration, rendering systemic antibiotic injections ineffective. Here, we test the hypothesis that implant coatings that reduce bacterial colonization would make planktonic bacteria within the periprosthetic environment more susceptible to conventional systemic antibiotic treatment. We covalently grafted zwitterionic polymer brushes poly(sulfobetaine methacryate) from Ti6Al4V surface to increase the substrate surface hydrophilicity and reduce staphylococcus aureus (S. aureus) adhesion. Using a mouse femoral intramedullary (IM) canal infection model, we showed that the anti-fouling coating applied to Ti6Al4V IM implants, when combined with a single vancomycin systemic injection, significantly suppressed both bacterial colonization on implant surfaces and the periprosthetic infections, outperforming either treatment alone. This work supports the hypothesis that grafting anti-fouling polymers to implant surfaces improves the efficacy of systemic antibiotic injections to combat periprosthetic infections.</p>
dc.identifier.submissionpathfaculty_pubs/2108
dc.contributor.departmentDepartment of Orthopedics and Physical Rehabilitation
dc.source.pages5896-5904


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