A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
Authors
Ramachandran, ShankarBanerjee, Navonil
Bhattacharya, Raja
Lemons, Michele L.
Florman, Jeremy
Lambert, Christopher M.
Touroutine, Denis
Alexander, Kellianne
Schoofs, Liliane
Alkema, Mark J
Beets, Isabel
Francis, Michael M.
Student Authors
Jeremy FlormanNavonil Banerjee
Kellianne Alexander
Academic Program
NeuroscienceDocument Type
Journal ArticlePublication Date
2021-11-12Keywords
C. elegansG protein-coupled receptor
cholecystokinin
local search
neural circuits
neuropeptide
neuroscience
Amino Acids, Peptides, and Proteins
Behavioral Neurobiology
Metadata
Show full item recordAbstract
Neuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks. Here, we show that the Caenorhabditis elegans NLP-12 neuropeptide system shapes responses to food availability by modulating the activity of head and body wall motor neurons through alternate G-protein coupled receptor (GPCR) targets, CKR-1 and CKR-2. We show ckr-2 deletion reduces body bend depth during movement under basal conditions. We demonstrate CKR-1 is a functional NLP-12 receptor and define its expression in the nervous system. In contrast to basal locomotion, biased CKR-1 GPCR stimulation of head motor neurons promotes turning during local searching. Deletion of ckr-1 reduces head neuron activity and diminishes turning while specific ckr-1 overexpression or head neuron activation promote turning. Thus, our studies suggest locomotor responses to changing food availability are regulated through conditional NLP-12 stimulation of head or body wall motor circuits.Source
Ramachandran S, Banerjee N, Bhattacharya R, Lemons ML, Florman J, Lambert CM, Touroutine D, Alexander K, Schoofs L, Alkema MJ, Beets I, Francis MM. A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior. Elife. 2021 Nov 12;10:e71747. doi: 10.7554/eLife.71747. PMID: 34766905; PMCID: PMC8626090. Link to article on publisher's site
DOI
10.7554/eLife.71747Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29919PubMed ID
34766905Related Resources
Rights
Copyright © 2021, Ramachandran et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.7554/eLife.71747
Scopus Count
Except where otherwise noted, this item's license is described as Copyright © 2021, Ramachandran et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.