YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
UMass Chan Affiliations
Graduate School of Biomedical SciencesProgram in Bioinformatics and Integrative Biology
Document Type
Journal ArticlePublication Date
2021-08-31Keywords
TAZYAP
cancer
cancer biology
cellular transformation
chromosomes
gene expression
gene regulation
human
transcriptional co-activator
Amino Acids, Peptides, and Proteins
Cancer Biology
Genetics and Genomics
Neoplasms
Metadata
Show full item recordAbstract
The YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD proteins. Here, we show that YAP and TAZ are also recruited by JUNB (a member of the AP-1 family) and STAT3, key transcription factors that mediate an epigenetic switch linking inflammation to cellular transformation. YAP and TAZ directly interact with JUNB and STAT3 via a WW domain important for transformation, and they stimulate transcriptional activation by AP-1 proteins. JUNB, STAT3, and TEAD co-localize at virtually all YAP/TAZ target sites, yet many target sites only contain individual AP-1, TEAD, or STAT3 motifs. This observation and differences in relative crosslinking efficiencies of JUNB, TEAD, and STAT3 at YAP/TAZ target sites suggest that YAP/TAZ is recruited by different forms of an AP-1/STAT3/TEAD complex depending on the recruiting motif. The different classes of YAP/TAZ target sites are associated with largely non-overlapping genes with distinct functions. A small minority of target sites are YAP- or TAZ-specific, and they are associated with different sequence motifs and gene classes from shared YAP/TAZ target sites. Genes containing either the AP-1 or TEAD class of YAP/TAZ sites are associated with poor survival of breast cancer patients with the triple-negative form of the disease.Source
He L, Pratt H, Gao M, Wei F, Weng Z, Struhl K. YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation. Elife. 2021 Aug 31;10:e67312. doi: 10.7554/eLife.67312. PMID: 34463254; PMCID: PMC8463077. Link to article on publisher's site
DOI
10.7554/eLife.67312Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29920PubMed ID
34463254Related Resources
Rights
Copyright © 2021, He et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.7554/eLife.67312
Scopus Count
Except where otherwise noted, this item's license is described as Copyright © 2021, He et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.