IL-6 boosts synaptogenesis STAT!

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Authors
Faust, Travis E.
Schafer, Dorothy P
UMass Chan Affiliations
Schafer Lab
Neurobiology
Document Type
Journal Article
Publication Date
2021-11-09
Keywords
Amino Acids, Peptides, and Proteins
Developmental Neuroscience
Immunity
Molecular and Cellular Neuroscience

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Link to Full Text
https://doi.org/10.1016/j.immuni.2021.10.010
Abstract
Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Source

Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 Nov 9;54(11):2444-2446. doi: 10.1016/j.immuni.2021.10.010. PMID: 34758335. Link to article on publisher's site
DOI
10.1016/j.immuni.2021.10.010
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29925
PubMed ID
34758335
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