IL-6 boosts synaptogenesis STAT!
| dc.contributor.author | Faust, Travis E | |
| dc.contributor.author | Schafer, Dorothy P | |
| dc.date | 2022-08-11T08:08:28.000 | |
| dc.date.accessioned | 2022-08-23T15:56:14Z | |
| dc.date.available | 2022-08-23T15:56:14Z | |
| dc.date.issued | 2021-11-09 | |
| dc.date.submitted | 2021-12-20 | |
| dc.identifier.citation | <p>Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 Nov 9;54(11):2444-2446. doi: 10.1016/j.immuni.2021.10.010. PMID: 34758335. <a href="https://doi.org/10.1016/j.immuni.2021.10.010">Link to article on publisher's site</a></p> | |
| dc.identifier.issn | 1074-7613 (Linking) | |
| dc.identifier.doi | 10.1016/j.immuni.2021.10.010 | |
| dc.identifier.pmid | 34758335 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/29925 | |
| dc.description.abstract | Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34758335&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://doi.org/10.1016/j.immuni.2021.10.010 | |
| dc.subject | Amino Acids, Peptides, and Proteins | |
| dc.subject | Developmental Neuroscience | |
| dc.subject | Immunity | |
| dc.subject | Molecular and Cellular Neuroscience | |
| dc.title | IL-6 boosts synaptogenesis STAT! | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Immunity | |
| dc.source.volume | 54 | |
| dc.source.issue | 11 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/2128 | |
| dc.identifier.contextkey | 26908867 | |
| html.description.abstract | <p>Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.</p> | |
| dc.identifier.submissionpath | faculty_pubs/2128 | |
| dc.contributor.department | Schafer Lab | |
| dc.contributor.department | Neurobiology | |
| dc.source.pages | 2444-2446 |
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