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    The abbreviated pluripotent cell cycle

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    Authors
    Kapinas, Kristina
    Grandy, Rodrigo
    Ghule, Prachi N.
    Medina, Ricardo F.
    Becker, Klaus A.
    Pardee, Arthur B.
    Zaidi, Sayyed K.
    Lian, Jane B.
    Stein, Janet L.
    Van Wijnen, Andre J.
    Stein, Gary S.
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    UMass Chan Affiliations
    Department of Cell and Developmental Biology
    Document Type
    Journal Article
    Publication Date
    2013-01-01
    Keywords
    Animals
    Cell Cycle
    Cell Nucleus
    Embryonic Stem Cells
    Gene Expression Regulation
    Genes, myc
    Histones
    Humans
    MicroRNAs
    Pluripotent Stem Cells
    Cell Biology
    Cellular and Molecular Physiology
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    Link to Full Text
    http://dx.doi.org/10.1002/jcp.24104
    Abstract
    Human embryonic stem cells (hESCs) and induced pluripotent stem cells proliferate rapidly and divide symmetrically producing equivalent progeny cells. In contrast, lineage committed cells acquire an extended symmetrical cell cycle. Self-renewal of tissue-specific stem cells is sustained by asymmetric cell division where one progeny cell remains a progenitor while the partner progeny cell exits the cell cycle and differentiates. There are three principal contexts for considering the operation and regulation of the pluripotent cell cycle: temporal, regulatory, and structural. The primary temporal context that the pluripotent self-renewal cell cycle of hESCs is a short G1 period without reducing periods of time allocated to S phase, G2, and mitosis. The rules that govern proliferation in hESCs remain to be comprehensively established. However, several lines of evidence suggest a key role for the naive transcriptome of hESCs, which is competent to stringently regulate the embryonic stem cell (ESC) cell cycle. This supports the requirements of pluripotent cells to self-propagate while suppressing expression of genes that confer lineage commitment and/or tissue specificity. However, for the first time, we consider unique dimensions to the architectural organization and assembly of regulatory machinery for gene expression in nuclear microenviornments that define parameters of pluripotency. From both fundamental biological and clinical perspectives, understanding control of the abbreviated ESC cycle can provide options to coordinate control of proliferation versus differentiation. Wound healing, tissue engineering, and cell-based therapy to mitigate developmental aberrations illustrate applications that benefit from knowledge of the biology of the pluripotent cell cycle.
    Source
    J Cell Physiol. 2013 Jan;228(1):9-20. doi: 10.1002/jcp.24104. Link to article on publisher's site
    DOI
    10.1002/jcp.24104
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29990
    PubMed ID
    22552993
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcp.24104
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