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Releasing the brakes on a chromatin-remodeling enzyme

dc.contributor.authorManning, Benjamin J.
dc.contributor.authorPeterson, Craig L.
dc.date2022-08-11T08:08:29.000
dc.date.accessioned2022-08-23T15:56:37Z
dc.date.available2022-08-23T15:56:37Z
dc.date.issued2013-01-01
dc.date.submitted2013-07-26
dc.identifier.citationNat Struct Mol Biol. 2013 Jan;20(1):5-7. doi: 10.1038/nsmb.2482. <a href="http://dx.doi.org/10.1038/nsmb.2482">Link to article on publisher's site</a>
dc.identifier.issn1545-9985 (Linking)
dc.identifier.doi10.1038/nsmb.2482
dc.identifier.pmid23288358
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30007
dc.description.abstractChromatin-remodeling enzymes use the energy from ATP hydrolysis to mobilize, disrupt or change the histone composition of nucleosomes, facilitating nearly every nuclear event. Two recent studies indicate that remodeling enzymes harness the power of an ancient constitutively active DNA translocase and that different remodeling enzymes may use specialized coupling domains that communicate the presence of nucleosomal epitopes to regulate translocase and remodeling activity.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23288358&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/nsmb.2482
dc.subjectAdenosine Triphosphate
dc.subjectAnimals
dc.subjectCell Cycle
dc.subjectChromatin
dc.subject*Chromatin Assembly and Disassembly
dc.subjectDNA
dc.subjectDNA Helicases
dc.subjectHistones
dc.subjectHumans
dc.subjectNuclear Proteins
dc.subjectNucleosomes
dc.subjectPromoter Regions, Genetic
dc.subjectTranscription, Genetic
dc.subjectCell Biology
dc.subjectMolecular Biology
dc.subjectStructural Biology
dc.titleReleasing the brakes on a chromatin-remodeling enzyme
dc.typeJournal Article
dc.source.journaltitleNature structural and molecular biology
dc.source.volume20
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/241
dc.identifier.contextkey4352252
html.description.abstract<p>Chromatin-remodeling enzymes use the energy from ATP hydrolysis to mobilize, disrupt or change the histone composition of nucleosomes, facilitating nearly every nuclear event. Two recent studies indicate that remodeling enzymes harness the power of an ancient constitutively active DNA translocase and that different remodeling enzymes may use specialized coupling domains that communicate the presence of nucleosomal epitopes to regulate translocase and remodeling activity.</p>
dc.identifier.submissionpathfaculty_pubs/241
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages5-7


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