Authors
Houston, Isaac B.Peter, Cyril J.
Mitchell, Amanda C.
Straubhaar, Juerg R.
Rogaev, Evgeny I.
Akbarian, Schahram
UMass Chan Affiliations
Program in Molecular MedicineDepartment of Psychiatry, Brudnick Neuropsychiatric Research Institute
Document Type
Journal ArticlePublication Date
2013-01-01Keywords
Brain ChemistryDNA Methylation
Epigenesis, Genetic
Humans
Mental Disorders
Cell and Developmental Biology
Mental Disorders
Molecular and Cellular Neuroscience
Neuroscience and Neurobiology
Psychiatry
Psychiatry and Psychology
Metadata
Show full item recordAbstract
Many cellular constituents in the human brain permanently exit from the cell cycle during pre- or early postnatal development, but little is known about epigenetic regulation of neuronal and glial epigenomes during maturation and aging, including changes in mood and psychosis spectrum disorders and other cognitive or emotional disease. Here, we summarize the current knowledge base as it pertains to genome organization in the human brain, including the regulation of DNA cytosine methylation and hydroxymethylation, and a subset of (altogether >100) residue-specific histone modifications associated with gene expression, and silencing and various other functional chromatin states. We propose that high-resolution mapping of epigenetic markings in postmortem brain tissue or neural cultures derived from induced pluripotent cells (iPS), in conjunction with transcriptome profiling and whole-genome sequencing, will increasingly be used to define the molecular pathology of specific cases diagnosed with depression, schizophrenia, autism, or other major psychiatric disease. We predict that these highly integrative explorations of genome organization and function will provide an important alternative to conventional approaches in human brain studies, which mainly are aimed at uncovering group effects by diagnosis but generally face limitations because of cohort size.Source
Neuropsychopharmacology. 2013 Jan;38(1):183-97. doi: 10.1038/npp.2012.78. Link to article on publisher's siteDOI
10.1038/npp.2012.78Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30009PubMed ID
22643929Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/npp.2012.78