Neuropsychological correlates of symptom dimensions in inpatients with major depressive disorder
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2013-05-15Keywords
DepressionSymptom dimensions
Neuropsychological impairment
Mental Disorders
Psychiatric and Mental Health
Psychiatry
Metadata
Show full item recordAbstract
Symptoms of major depressive disorder (MDD) manifest variably across individuals. Accordingly, recent models of the disorder imply that MDD may be characterized according to independent symptom dimensions. In particular, several studies reveal that depression may be characterized along dimensions of negative affect, agitation and hostility, and lassitude and malaise. No research has examined the relationship between these dimensions and neuropsychological function. Towards this end, 133 in patients with unipolar MDD and 17 people without psychiatric illness were administered a brief battery of neuropsychological tests and the MMPI-2. Paralleling earlier research, principal component analysis of the MMPI-2 revealed symptom dimensions of negative affect, agitation, and lassitude and malaise. Multiple regression analyses showed that the negative affect and agitation dimensions accounted for significant variance on measures of executive function, speed of information processing, new learning, dexterity, and overall impairment. Lassitude and malaise failed to correspond with neuropsychological performance. Implications of these data for clinical practice and neural models of MDD are discussed.Source
Psychiatry Res. 2013 May 15;207(1-2):61-7. doi: 10.1016/j.psychres.2013.01.018. Link to article on publisher's siteDOI
10.1016/j.psychres.2013.01.018Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30034PubMed ID
23433872Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.psychres.2013.01.018