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    Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk

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    Authors
    McManus, David D.
    Beaulieu, Lea M.
    Mick, Eric
    Tanriverdi, Kahraman
    Larson, Martin G.
    Keaney, John F. Jr.
    Benjamin, Emelia J.
    Freedman, Jane E.
    UMass Chan Affiliations
    Meyers Primary Care Institute
    Department of Quantitative Health Sciences
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2013-11-01
    Keywords
    Aged
    Blood Platelets
    Body Weight
    C-Reactive Protein
    Cardiovascular Diseases
    Female
    Gene Expression
    Humans
    Immunologic Factors
    Interleukin-6
    Male
    Massachusetts
    Middle Aged
    Obesity
    RNA
    Risk Factors
    UMCCTS funding
    Cardiology
    Cardiovascular Diseases
    Epidemiology
    Genetics and Genomics
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289138/
    Abstract
    OBJECTIVE: Cardiovascular disease is a complex disorder influenced by interactions of genetic variants with environmental factors. However, there is no information from large community-based studies examining the relationship of circulating cell-specific RNA to inflammatory proteins. In light of the associations among inflammatory biomarkers, obesity, platelet function, and cardiovascular disease, we sought to examine the relationships of C-reactive protein (CRP) and interleukin-6 (IL-6) to the expression of key inflammatory transcripts in platelets. APPROACH AND RESULTS: We quantified circulating levels of CRP and IL-6 in 1625 participants of the Framingham Heart Study (FHS) Offspring cohort examination 8 (mean age, 66.6 ± 6.6 years; 46% men). We measured the expression of 15 relevant genes by high-throughput quantitative reverse transcriptase polymerase chain reaction from platelet-derived RNA and used multivariable regression to relate serum concentrations of CRP and IL-6 with gene expression. Levels of CRP and IL-6 were associated with 10 of the 15 platelet-derived inflammatory transcripts, ALOX5, CRP, IFIT1, IL6, PTGER2, S100A9, SELENBP1, TLR2, TLR4, and TNFRSF1B (P CONCLUSIONS: Our data highlight the strong connection between the circulating inflammatory biomarkers CRP and IL-6 and platelet gene expression, adjusting for cardiovascular disease risk factors. Our results also suggest that body weight may directly influence these associations.
    Source

    McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF Jr, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2666-73. doi: 10.1161/ATVBAHA.112.301112. Link to article on publisher's site

    DOI
    10.1161/ATVBAHA.112.301112
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30054
    PubMed ID
    23968978
    Related Resources

    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1161/ATVBAHA.112.301112
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    UMass Center for Clinical and Translational Science Supported Publications

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