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Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk
Authors
McManus, David DBeaulieu, Lea M.
Mick, Eric O.
Tanriverdi, Kahraman
Larson, Martin G.
Keaney, John F. Jr.
Benjamin, Emelia J.
Freedman, Jane E.
UMass Chan Affiliations
Meyers Primary Care InstituteDepartment of Quantitative Health Sciences
Department of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2013-11-01Keywords
AgedBlood Platelets
Body Weight
C-Reactive Protein
Cardiovascular Diseases
Female
Gene Expression
Humans
Immunologic Factors
Interleukin-6
Male
Massachusetts
Middle Aged
Obesity
RNA
Risk Factors
UMCCTS funding
Cardiology
Cardiovascular Diseases
Epidemiology
Genetics and Genomics
Metadata
Show full item recordAbstract
OBJECTIVE: Cardiovascular disease is a complex disorder influenced by interactions of genetic variants with environmental factors. However, there is no information from large community-based studies examining the relationship of circulating cell-specific RNA to inflammatory proteins. In light of the associations among inflammatory biomarkers, obesity, platelet function, and cardiovascular disease, we sought to examine the relationships of C-reactive protein (CRP) and interleukin-6 (IL-6) to the expression of key inflammatory transcripts in platelets. APPROACH AND RESULTS: We quantified circulating levels of CRP and IL-6 in 1625 participants of the Framingham Heart Study (FHS) Offspring cohort examination 8 (mean age, 66.6 ± 6.6 years; 46% men). We measured the expression of 15 relevant genes by high-throughput quantitative reverse transcriptase polymerase chain reaction from platelet-derived RNA and used multivariable regression to relate serum concentrations of CRP and IL-6 with gene expression. Levels of CRP and IL-6 were associated with 10 of the 15 platelet-derived inflammatory transcripts, ALOX5, CRP, IFIT1, IL6, PTGER2, S100A9, SELENBP1, TLR2, TLR4, and TNFRSF1B (P CONCLUSIONS: Our data highlight the strong connection between the circulating inflammatory biomarkers CRP and IL-6 and platelet gene expression, adjusting for cardiovascular disease risk factors. Our results also suggest that body weight may directly influence these associations.Source
McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF Jr, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2666-73. doi: 10.1161/ATVBAHA.112.301112. Link to article on publisher's site
DOI
10.1161/ATVBAHA.112.301112Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30054PubMed ID
23968978Related Resources
ae974a485f413a2113503eed53cd6c53
10.1161/ATVBAHA.112.301112