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    Adverse drug events after hospital discharge in older adults: types, severity, and involvement of Beers Criteria Medications

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    Authors
    Kanaan, Abir O.
    Donovan, Jennifer L.
    Duchin, Nerissa P.
    Field, Terry S.
    Tjia, Jennifer
    Cutrona, Sarah L.
    Gagne, Shawn J.
    Garber, Lawrence D.
    Preusse, Peggy
    Harrold, Leslie R.
    Gurwitz, Jerry H.
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    UMass Chan Affiliations
    Meyers Primary Care Institute
    Department of Medicine, Division of Geriatric Medicine
    Document Type
    Journal Article
    Publication Date
    2013-11-01
    Keywords
    Aged
    Drug-Related Side Effects and Adverse Reactions
    Female
    Humans
    Inappropriate Prescribing
    Male
    *Patient Discharge
    Severity of Illness Index
    Time Factors
    UMCCTS funding
    Geriatrics
    Pharmaceutical Preparations
    Show allShow less
    
    Metadata
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446728/
    Abstract
    OBJECTIVES: To characterize adverse drug events (ADEs) occurring within the high-risk 45-day period after hospitalization in older adults. DESIGN: Clinical pharmacists reviewed the ambulatory records of 1,000 consecutive discharges. SETTING: A large multispecialty group practice closely aligned with a Massachusetts-based health plan. PARTICIPANTS: Hospitalized individuals aged 65 and older discharged home. MEASUREMENTS: Possible drug-related incidents occurring during the 45-day period after hospitalization were identified and presented to a pair of physician-reviewers who classified incidents as to whether an ADE was present, whether the event was preventable, and the severity of the event. Medications implicated in ADEs were further characterized according to their inclusion in the 2012 Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. RESULTS: At least one ADE was identified during the 45-day period in 18.7% (n = 187) of the 1,000 discharges. Of the 242 ADEs identified, 35% (n = 84) were deemed preventable, of which 32% (n = 27) were characterized as serious, and 5% (n = 4) as life threatening. More than half of all ADEs occurred within the first 14 days after hospitalization. The percentage of ADEs in which Beers Criteria medications were implicated was 16.5% (n = 40). Beers criteria medications with both a high quality of evidence and strong strength of recommendation were implicated in 6.6% (n = 16) of the ADEs. CONCLUSION: ADEs are common and often preventable in older adults after hospital discharge, underscoring the need to address medication safety during this high-risk period in this vulnerable population. Beers criteria medications played a small role in these events, suggesting that efforts to improve the quality and safety of medication use during this critical transition period must extend beyond a singular focus on Beers criteria medications
    Source

    Kanaan AO, Donovan JL, Duchin NP, Field TS, Tjia J, Cutrona SL, Gagne SJ, Garber L, Preusse P, Harrold LR, Gurwitz JH. Adverse drug events after hospital discharge in older adults: types, severity, and involvement of Beers Criteria Medications. J Am Geriatr Soc. 2013 Nov;61(11):1894-9. doi:10.1111/jgs.12504. Link to article on publisher's site

    DOI
    10.1111/jgs.12504
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30071
    PubMed ID
    24116689
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1111/jgs.12504
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