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    HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells

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    Authors
    Zhao, Hang
    Zhang, Xueqing
    Frazao, Josias Brito
    Condino-Neto, Antonio
    Newburger, Peter E.
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2013-05-03
    Keywords
    Homeodomain Proteins
    RNA, Long Untranslated
    Apoptosis
    Apoptosis Regulatory Proteins
    Leukemia, Promyelocytic, Acute
    Cancer Biology
    Hemic and Lymphatic Diseases
    Neoplasms
    
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    Link to Full Text
    http://dx.doi.org/10.1002/jcb.24586
    Abstract
    HOXA cluster antisense RNA 2 (HOXA-AS2) is a long non-coding RNA located between the HOXA3 and HOXA4 genes in the HOXA cluster. Its transcript is expressed in NB4 promyelocytic leukemia cells and human peripheral blood neutrophils, and expression is increased in NB4 cells treated with all trans retinoic acid (ATRA). Knockdown of HOXA-AS2 expression by transduced shRNA decreases the number of viable cells and increases the proportion of apoptotic cells, measured by annexin V binding and by activity and cleavage of caspases-3, -8, and -9. The increase in death of HOXA-AS2 knockdown cells was accompanied by an elevated TNF-related apoptosis-inducing ligand (TRAIL) levels, but ATRA-induced NB4 cells treated with TRAIL did show an increase in HOXA-AS2 expression. These results demonstrate that ATRA induction of HOXA-AS2 suppresses ATRA-induced apoptosis, possibly through a TRAIL-mediated pathway. HOXA-AS2-mediated negative regulation thus contributes to the fine-tuning of apoptosis during ATRA-induced myeloid differentiation in NB4 cells. J. Cell. Biochem. (c) 2013 Wiley Periodicals, Inc.
    Source
    J Cell Biochem. 2013 May 3. doi: 10.1002/jcb.24586. Link to article on publisher's site
    DOI
    10.1002/jcb.24586
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30094
    PubMed ID
    23649634
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcb.24586
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    UMass Chan Faculty and Researcher Publications

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