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    An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells

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    Authors
    Kutikov, Artem B.
    Song, Jie
    UMass Chan Affiliations
    Department of Cell and Developmental Biology
    Department of Orthopedics and Physical Rehabilitation
    Document Type
    Journal Article
    Publication Date
    2013-09-01
    Keywords
    Absorbable Implants
    Animals
    Bone Substitutes
    Cell Differentiation
    Cell Proliferation
    Cells, Cultured
    Durapatite
    Equipment Design
    Equipment Failure Analysis
    Gene Expression Regulation
    Hydrophobic and Hydrophilic Interactions
    Lactates
    Male
    Materials Testing
    Mesenchymal Stromal Cells
    Osteoblasts
    Osteogenesis
    Polyethylene Glycols
    Rats
    *Tissue Scaffolds
    Biomaterials
    Cell and Developmental Biology
    Genetic Phenomena
    Molecular, Cellular, and Tissue Engineering
    Orthopedics
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    Link to Full Text
    http://dx.doi.org/10.1016/j.actbio.2013.06.013
    Abstract
    Electrospun polymer/hydroxyapatite (HA) composites combining biodegradability with osteoconductivity are attractive for skeletal tissue engineering applications. However, most biodegradable polymers such as poly(lactic acid) (PLA) are hydrophobic and do not blend with adequate interfacial adhesion with HA, compromising the structural homogeneity, mechanical integrity and biological performance of the composite. To overcome this challenge, we combined a hydrophilic polyethylene glycol (PEG) block with poly(d,l-lactic acid) to improve the adhesion of the degradable polymer with HA. The amphiphilic triblock copolymer PLA-PEG-PLA (PELA) improved the stability of HA-PELA suspension at 25wt.% HA content, which was readily electrospun into HA-PELA composite scaffolds with uniform fiber dimensions. HA-PELA was highly extensible (failure strain>200% vs. 100 degrees for HA-PLA), and exhibited an 8-fold storage modulus increase (unlike deterioration for HA-PLA) upon hydration, owing to the favorable interaction between HA and PEG. HA-PELA also better promoted osteochondral lineage commitment of bone marrow stromal cells in unstimulated culture and supported far more potent osteogenic gene expression upon induction than HA-PLA. We demonstrate that the chemical incorporation of PEG is an effective strategy to improve the performance of degradable polymer/HA composites for bone tissue engineering applications.
    Source

    Kutikov AB, Song J. An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells. Acta Biomater. 2013 Sep;9(9):8354-64. doi:10.1016/j.actbio.2013.06.013. Link to article on publisher's site

    DOI
    10.1016/j.actbio.2013.06.013
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30139
    PubMed ID
    23791675
    Notes

    First author Artem B. Kutikov is a doctoral student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.actbio.2013.06.013
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