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UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2013-08-01Keywords
AnimalsCommunicable Diseases
Disease Models, Animal
Humans
Mice
Translational Medical Research
Animal Experimentation and Research
Immunology and Infectious Disease
Pathology
Pharmaceutical Preparations
Therapeutics
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Show full item recordAbstract
Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice engrafted with functional human cells and tissues, termed 'humanized' mice, represent a critical pre-clinical bridge for in vivo studies of human pathogens. Recent advances in the development of humanized mice have allowed in vivo studies of multiple human infectious agents providing novel insights into their pathogenesis that was otherwise not possible.Source
Brehm MA, Jouvet N, Greiner DL, Shultz LD. Humanized mice for the study of infectious diseases. Curr Opin Immunol. 2013 Aug;25(4):428-35. doi:10.1016/j.coi.2013.05.012. Link to article on publisher's site
DOI
10.1016/j.coi.2013.05.012Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30143PubMed ID
23751490Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.coi.2013.05.012