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dc.contributor.authorRittershaus, Emily S. C.
dc.contributor.authorBaek, Seung-Hun
dc.contributor.authorSassetti, Christopher M.
dc.date2022-08-11T08:08:30.000
dc.date.accessioned2022-08-23T15:57:16Z
dc.date.available2022-08-23T15:57:16Z
dc.date.issued2013-06-12
dc.date.submitted2014-05-13
dc.identifier.citation<p>Rittershaus ES, Baek SH, Sassetti CM. The normalcy of dormancy: common themes in microbial quiescence. Cell Host Microbe. 2013 Jun 12;13(6):643-51. doi:10.1016/j.chom.2013.05.012. <a href="http://dx.doi.org/10.1016/j.chom.2013.05.012">Link to article on publisher's site</a></p>
dc.identifier.issn1931-3128 (Linking)
dc.identifier.doi10.1016/j.chom.2013.05.012
dc.identifier.pmid23768489
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30156
dc.description.abstractAll microorganisms are exposed to periodic stresses that inhibit growth. Many bacteria and fungi weather these periods by entering a hardy, nonreplicating state, often termed quiescence or dormancy. When this occurs during an infection, the resulting slowly growing pathogen is able to tolerate both immune insults and prolonged antibiotic exposure. While the stresses encountered in a free-living environment may differ from those imposed by host immunity, these growth-limiting conditions impose common pressures, and many of the corresponding microbial responses appear to be universal. In this review, we discuss the common features of these growth-limited states, which suggest new approaches for treating chronic infections such as tuberculosis.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23768489&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743100/
dc.subjectBacteria
dc.subjectDrug Resistance, Microbial
dc.subjectFungi
dc.subject*Stress, Physiological
dc.subjectBacteria
dc.subjectMicrobial Physiology
dc.subjectPathology
dc.titleThe normalcy of dormancy: common themes in microbial quiescence
dc.typeJournal Article
dc.source.journaltitleCell host and microbe
dc.source.volume13
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/398
dc.identifier.contextkey5574379
html.description.abstract<p>All microorganisms are exposed to periodic stresses that inhibit growth. Many bacteria and fungi weather these periods by entering a hardy, nonreplicating state, often termed quiescence or dormancy. When this occurs during an infection, the resulting slowly growing pathogen is able to tolerate both immune insults and prolonged antibiotic exposure. While the stresses encountered in a free-living environment may differ from those imposed by host immunity, these growth-limiting conditions impose common pressures, and many of the corresponding microbial responses appear to be universal. In this review, we discuss the common features of these growth-limited states, which suggest new approaches for treating chronic infections such as tuberculosis.</p>
dc.identifier.submissionpathfaculty_pubs/398
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.source.pages643-51


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