AuthorsGacek, Richard R.
UMass Chan AffiliationsDepartment of Otolaryngology
Document TypeJournal Article
Nervous System Diseases
Pathological Conditions, Signs and Symptoms
MetadataShow full item record
AbstractThe recurrent nature of the 3 most common vestibulopathies suggests a recurrent cause. Histopathology in temporal bones from patients with these syndromes - vestibular neuronitis (VN, n = 7), Meniere's disease (MD, n = 8) and benign paroxysmal positional vertigo (BPPV, n = 5) - shows focal degeneration of vestibular nerve axons and degenerated nearby facial nerve meatal ganglion cells. Transmission electron microscopic confirmation of intracytoplasmic viral particles in surgically excised vestibular nerves from patients with VN and MD support a viral etiology in these vestibulopathies. Antiviral treatment of these syndromes in a series of 211 patients with a 3- to 8-year follow-up resulted in complete control of vertigo in VN (88%), MD (90%) and BPPV (60%).
Gacek RR. A perspective on recurrent vertigo. ORL J Otorhinolaryngol Relat Spec. 2013;75(2):91-107. doi: 10.1159/000348710. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/30171