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Circulating levels of soluble MICB in infants with symptomatic primary dengue virus infections

dc.contributor.authorLibraty, Daniel H.
dc.contributor.authorZhang, Lei
dc.contributor.authorObcena, AnaMae
dc.contributor.authorBrion, Job D.
dc.contributor.authorCapeding, Rosario Z.
dc.date2022-08-11T08:08:30.000
dc.date.accessioned2022-08-23T15:57:23Z
dc.date.available2022-08-23T15:57:23Z
dc.date.issued2014-05-28
dc.date.submitted2014-10-20
dc.identifier.citationPLoS One. 2014 May 28;9(5):e98509. doi: 10.1371/journal.pone.0098509. eCollection 2014. <a href="http://dx.doi.org/10.1371/journal.pone.0098509">Link to article on publisher's site</a>
dc.identifier.issn1932-6203 (Linking)
dc.identifier.doi10.1371/journal.pone.0098509
dc.identifier.pmid24869966
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30183
dc.description.abstractDengue is the most prevalent arthropod-borne viral illness in humans. A MHC class I polypeptide-related sequence B (MICB) single nucleotide polymorphism (SNP) was previously associated with symptomatic dengue compared to non-dengue causes of acute febrile illnesses in infants. We measured circulating levels of soluble (s)MICB in the sera of infants with symptomatic primary dengue virus infections. We found that serum levels of sMICB increased between pre-infection and acute illness among infants with symptomatic primary dengue virus infections. The likelihood of being hospitalized with an acute primary DENV infection during infancy also tended to be higher with increasing acute illness sMICB levels. The elevation of sMICB during acute primary DENV infections in infants likely represents an immune evasion strategy and contributes to the severity of the acute illness.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24869966&dopt=Abstract">Link to Article in PubMed</a>
dc.rights© 2014 Libraty et al. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectImmunology of Infectious Disease
dc.subjectImmunoprophylaxis and Therapy
dc.subjectVirus Diseases
dc.titleCirculating levels of soluble MICB in infants with symptomatic primary dengue virus infections
dc.typeJournal Article
dc.source.journaltitlePloS one
dc.source.volume9
dc.source.issue5
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1424&amp;context=faculty_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/425
dc.identifier.contextkey6251703
refterms.dateFOA2022-08-23T15:57:23Z
html.description.abstract<p>Dengue is the most prevalent arthropod-borne viral illness in humans. A MHC class I polypeptide-related sequence B (MICB) single nucleotide polymorphism (SNP) was previously associated with symptomatic dengue compared to non-dengue causes of acute febrile illnesses in infants. We measured circulating levels of soluble (s)MICB in the sera of infants with symptomatic primary dengue virus infections. We found that serum levels of sMICB increased between pre-infection and acute illness among infants with symptomatic primary dengue virus infections. The likelihood of being hospitalized with an acute primary DENV infection during infancy also tended to be higher with increasing acute illness sMICB levels. The elevation of sMICB during acute primary DENV infections in infants likely represents an immune evasion strategy and contributes to the severity of the acute illness.</p>
dc.identifier.submissionpathfaculty_pubs/425
dc.contributor.departmentDepartment of Medicine, Division of Immunology and Infectious Diseases
dc.source.pagese98509


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© 2014 Libraty et al. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2014 Libraty et al. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.