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    New developments in gout

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    Authors
    Harrold, Leslie R.
    UMass Chan Affiliations
    Department of Orthopedics and Physical Rehabilitation
    Department of Medicine, Division of Rheumatology
    Meyers Primary Care Institute
    Document Type
    Journal Article
    Publication Date
    2013-05-01
    Keywords
    Gout
    gout
    guidelines
    interleukin-1b
    urate-lowering therapy
    Amino Acids, Peptides, and Proteins
    Biological Factors
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities
    Investigative Techniques
    Musculoskeletal Diseases
    Nutritional and Metabolic Diseases
    Rheumatology
    Therapeutics
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    Link to Full Text
    http://dx.doi.org/10.1097/BOR.0b013e32835fd5e5
    Abstract
    PURPOSE OF REVIEW: Gout is the most common type of inflammatory arthritis. This review summarizes the most recent studies on newer therapeutics, disease management strategies and treatment recommendations. RECENT FINDINGS: There are several new therapeutic agents being investigated both for the management of the acute gout symptoms, targeting interleukin-1beta, as well as urate-lowering therapies including uricase and inhibitors of renal urate transporter proteins. Interventions led by pharmacists and nurses, which include patient education, lifestyle advice, monitoring and titration of urate-lowering medications have been implemented to improve gout management. Recently, the American College of Rheumatology has published guidelines for nonpharmacologic and pharmacologic therapeutic approaches for hyperuricemia and acute gouty arthritis. SUMMARY: New therapeutic agents targeting the mechanism of inflammation (IL-1beta) are under investigation. In addition, new urate-lowering medications to be used alone or in combination with allopurinol are undergoing rigorous evaluation to use for patients not responding to or unable to take current therapies. There is also increasing interest in redesigning clinical care to improve patient education, self-management training and urate-lowering medication titration. Although we await results of these investigations, the American College of Rheumatology treatment guidelines provide a framework for clinicians in order to provide optimal gout care.
    Source

    Curr Opin Rheumatol. 2013 May;25(3):304-9. doi: 10.1097/BOR.0b013e32835fd5e5. Link to article on publisher's site

    DOI
    10.1097/BOR.0b013e32835fd5e5
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30194
    PubMed ID
    23466959
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1097/BOR.0b013e32835fd5e5
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