Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
UMass Chan Affiliations
Department of Microbiology and Physiological SystemsDocument Type
Journal ArticlePublication Date
2013-10-01Keywords
AnimalsCell Differentiation
Humans
Immune Tolerance
Infection
T-Lymphocytes
Thymus Gland
Thymus
infection
T cell repertoires
anti-microbial response
thymic microenvironment
Bacterial Infections and Mycoses
Biological Factors
Cells
Hemic and Immune Systems
Immunology and Infectious Disease
Immunopathology
Medical Immunology
Pathology
Metadata
Show full item recordAbstract
The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation.Source
Trends Immunol. 2013 Oct;34(10):502-10. doi: 10.1016/j.it.2013.06.004. Link to article on publisher's site
DOI
10.1016/j.it.2013.06.004Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30213PubMed ID
23871487Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.it.2013.06.004