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dc.contributor.authorNunes-Alves, Claudio
dc.contributor.authorNobrega, Claudia
dc.contributor.authorBehar, Samuel M.
dc.contributor.authorCorreia-Neves, Margarida
dc.date2022-08-11T08:08:30.000
dc.date.accessioned2022-08-23T15:57:30Z
dc.date.available2022-08-23T15:57:30Z
dc.date.issued2013-10-01
dc.date.submitted2014-10-24
dc.identifier.citation<p>Trends Immunol. 2013 Oct;34(10):502-10. doi: 10.1016/j.it.2013.06.004. <a href="http://dx.doi.org/10.1016/j.it.2013.06.004">Link to article on publisher's site</a></p>
dc.identifier.issn1471-4906 (Linking)
dc.identifier.doi10.1016/j.it.2013.06.004
dc.identifier.pmid23871487
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30213
dc.description.abstractThe thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23871487&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879077/
dc.subjectAnimals
dc.subjectCell Differentiation
dc.subjectHumans
dc.subjectImmune Tolerance
dc.subjectInfection
dc.subjectT-Lymphocytes
dc.subjectThymus Gland
dc.subjectThymus
dc.subjectinfection
dc.subjectT cell repertoires
dc.subjectanti-microbial response
dc.subjectthymic microenvironment
dc.subjectBacterial Infections and Mycoses
dc.subjectBiological Factors
dc.subjectCells
dc.subjectHemic and Immune Systems
dc.subjectImmunology and Infectious Disease
dc.subjectImmunopathology
dc.subjectMedical Immunology
dc.subjectPathology
dc.titleTolerance has its limits: how the thymus copes with infection
dc.typeJournal Article
dc.source.journaltitleTrends in immunology
dc.source.volume34
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/461
dc.identifier.contextkey6282117
html.description.abstract<p>The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation.</p>
dc.identifier.submissionpathfaculty_pubs/461
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.source.pages502-10


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