The Cellient automated cell block system is useful in the differential diagnosis of atypical glandular cells in Papanicolaou tests
UMass Chan Affiliations
Department of PathologyDocument Type
Journal ArticlePublication Date
2014-01-01Keywords
AdenocarcinomaAdult
Aged
Aged, 80 and over
Automation
Biopsy, Needle
Carcinoma, Squamous Cell
Cohort Studies
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Middle Aged
Neoplasms, Glandular and Epithelial
Papanicolaou Test
Retrospective Studies
Sensitivity and Specificity
Tissue Embedding
Uterine Cervical Dysplasia
Uterine Cervical Neoplasms
Diagnosis
Neoplasms
Obstetrics and Gynecology
Pathology
Metadata
Show full item recordAbstract
BACKGROUND: Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests. METHODS: A total of 148 patients with an AGC diagnosis based on Pap tests by cytotechnologists and referred to cytopathologists were studied. Among these patients, there were 68 patients with CB preparations and 80 patients with Pap tests only (TP-AGC group). Follow-up results by Pap tests or biopsies were obtained in 117 of 148 patients. The median follow-up was 13 months (range, 1 month-36 months). RESULTS: Of the 68 patients with CBs, 31 (46%) were reclassified as negative for dysplasia or low-grade intraepithelial lesion; 30 patients (44%) retained a diagnosis of AGC (CB-AGC group); and 7 patients (10%) were given specific diagnoses of high-grade intraepithelial lesion (3 patients), endocervical adenocarcinoma in situ (1 patient), and invasive adenocarcinoma (3 patients). On follow-up, the CB-AGC group was found to have a significantly lower rate of negative/low-grade squamous intraepithelial lesion diagnoses compared with the TP-AGC group (55% vs 85%; P = .006). The CB-AGC group had a significantly higher rate of endocervical or endometrial adenocarcinoma compared with the TP-AGC group (36% vs 8%; P = .003) at the time of follow-up. The rates of high-grade squamous intraepithelial lesion were not found to be statistically different between these 2 groups (9% vs 7%; P = .66). CONCLUSIONS: The Cellient CB is a useful technique to further categorize a diagnosis of AGC on Pap tests. Using the Cellient CB system, the pathologist has the ability to improve the diagnostic accuracy of AGC so that unnecessary colposcopic evaluation or biopsies can be avoided.Source
Cancer Cytopathol. 2014 Jan;122(1):8-14. doi: 10.1002/cncy.21343. Epub 2013 Aug 20. Link to article on publisher's siteDOI
10.1002/cncy.21343Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30251PubMed ID
23963870Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/cncy.21343