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    The Cellient automated cell block system is useful in the differential diagnosis of atypical glandular cells in Papanicolaou tests

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    Authors
    Xing, Wei
    Hou, April Y.
    Fischer, Andrew H.
    Owens, Christopher L.
    Jiang, Zhong
    UMass Chan Affiliations
    Department of Pathology
    Document Type
    Journal Article
    Publication Date
    2014-01-01
    Keywords
    Adenocarcinoma
    Adult
    Aged
    Aged, 80 and over
    Automation
    Biopsy, Needle
    Carcinoma, Squamous Cell
    Cohort Studies
    Diagnosis, Differential
    Female
    Humans
    Immunohistochemistry
    Middle Aged
    Neoplasms, Glandular and Epithelial
    Papanicolaou Test
    Retrospective Studies
    Sensitivity and Specificity
    Tissue Embedding
    Uterine Cervical Dysplasia
    Uterine Cervical Neoplasms
    Diagnosis
    Neoplasms
    Obstetrics and Gynecology
    Pathology
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    Link to Full Text
    http://dx.doi.org/10.1002/cncy.21343
    Abstract
    BACKGROUND: Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests. METHODS: A total of 148 patients with an AGC diagnosis based on Pap tests by cytotechnologists and referred to cytopathologists were studied. Among these patients, there were 68 patients with CB preparations and 80 patients with Pap tests only (TP-AGC group). Follow-up results by Pap tests or biopsies were obtained in 117 of 148 patients. The median follow-up was 13 months (range, 1 month-36 months). RESULTS: Of the 68 patients with CBs, 31 (46%) were reclassified as negative for dysplasia or low-grade intraepithelial lesion; 30 patients (44%) retained a diagnosis of AGC (CB-AGC group); and 7 patients (10%) were given specific diagnoses of high-grade intraepithelial lesion (3 patients), endocervical adenocarcinoma in situ (1 patient), and invasive adenocarcinoma (3 patients). On follow-up, the CB-AGC group was found to have a significantly lower rate of negative/low-grade squamous intraepithelial lesion diagnoses compared with the TP-AGC group (55% vs 85%; P = .006). The CB-AGC group had a significantly higher rate of endocervical or endometrial adenocarcinoma compared with the TP-AGC group (36% vs 8%; P = .003) at the time of follow-up. The rates of high-grade squamous intraepithelial lesion were not found to be statistically different between these 2 groups (9% vs 7%; P = .66). CONCLUSIONS: The Cellient CB is a useful technique to further categorize a diagnosis of AGC on Pap tests. Using the Cellient CB system, the pathologist has the ability to improve the diagnostic accuracy of AGC so that unnecessary colposcopic evaluation or biopsies can be avoided.
    Source
    Cancer Cytopathol. 2014 Jan;122(1):8-14. doi: 10.1002/cncy.21343. Epub 2013 Aug 20. Link to article on publisher's site
    DOI
    10.1002/cncy.21343
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30251
    PubMed ID
    23963870
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/cncy.21343
    Scopus Count
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