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dc.contributor.authorXing, Wei
dc.contributor.authorHou, April Y.
dc.contributor.authorFischer, Andrew H
dc.contributor.authorOwens, Christopher L.
dc.contributor.authorJiang, Zhong
dc.date2022-08-11T08:08:30.000
dc.date.accessioned2022-08-23T15:57:40Z
dc.date.available2022-08-23T15:57:40Z
dc.date.issued2014-01-01
dc.date.submitted2015-01-15
dc.identifier.citationCancer Cytopathol. 2014 Jan;122(1):8-14. doi: 10.1002/cncy.21343. Epub 2013 Aug 20. <a href="http://dx.doi.org/10.1002/cncy.21343">Link to article on publisher's site</a>
dc.identifier.issn1934-662X (Linking)
dc.identifier.doi10.1002/cncy.21343
dc.identifier.pmid23963870
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30251
dc.description.abstractBACKGROUND: Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests. METHODS: A total of 148 patients with an AGC diagnosis based on Pap tests by cytotechnologists and referred to cytopathologists were studied. Among these patients, there were 68 patients with CB preparations and 80 patients with Pap tests only (TP-AGC group). Follow-up results by Pap tests or biopsies were obtained in 117 of 148 patients. The median follow-up was 13 months (range, 1 month-36 months). RESULTS: Of the 68 patients with CBs, 31 (46%) were reclassified as negative for dysplasia or low-grade intraepithelial lesion; 30 patients (44%) retained a diagnosis of AGC (CB-AGC group); and 7 patients (10%) were given specific diagnoses of high-grade intraepithelial lesion (3 patients), endocervical adenocarcinoma in situ (1 patient), and invasive adenocarcinoma (3 patients). On follow-up, the CB-AGC group was found to have a significantly lower rate of negative/low-grade squamous intraepithelial lesion diagnoses compared with the TP-AGC group (55% vs 85%; P = .006). The CB-AGC group had a significantly higher rate of endocervical or endometrial adenocarcinoma compared with the TP-AGC group (36% vs 8%; P = .003) at the time of follow-up. The rates of high-grade squamous intraepithelial lesion were not found to be statistically different between these 2 groups (9% vs 7%; P = .66). CONCLUSIONS: The Cellient CB is a useful technique to further categorize a diagnosis of AGC on Pap tests. Using the Cellient CB system, the pathologist has the ability to improve the diagnostic accuracy of AGC so that unnecessary colposcopic evaluation or biopsies can be avoided.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23963870&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/cncy.21343
dc.subjectAdenocarcinoma
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAutomation
dc.subjectBiopsy, Needle
dc.subjectCarcinoma, Squamous Cell
dc.subjectCohort Studies
dc.subjectDiagnosis, Differential
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMiddle Aged
dc.subjectNeoplasms, Glandular and Epithelial
dc.subjectPapanicolaou Test
dc.subjectRetrospective Studies
dc.subjectSensitivity and Specificity
dc.subjectTissue Embedding
dc.subjectUterine Cervical Dysplasia
dc.subjectUterine Cervical Neoplasms
dc.subjectDiagnosis
dc.subjectNeoplasms
dc.subjectObstetrics and Gynecology
dc.subjectPathology
dc.titleThe Cellient automated cell block system is useful in the differential diagnosis of atypical glandular cells in Papanicolaou tests
dc.typeJournal Article
dc.source.journaltitleCancer cytopathology
dc.source.volume122
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/503
dc.identifier.contextkey6532227
html.description.abstract<p>BACKGROUND: Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests.</p> <p>METHODS: A total of 148 patients with an AGC diagnosis based on Pap tests by cytotechnologists and referred to cytopathologists were studied. Among these patients, there were 68 patients with CB preparations and 80 patients with Pap tests only (TP-AGC group). Follow-up results by Pap tests or biopsies were obtained in 117 of 148 patients. The median follow-up was 13 months (range, 1 month-36 months).</p> <p>RESULTS: Of the 68 patients with CBs, 31 (46%) were reclassified as negative for dysplasia or low-grade intraepithelial lesion; 30 patients (44%) retained a diagnosis of AGC (CB-AGC group); and 7 patients (10%) were given specific diagnoses of high-grade intraepithelial lesion (3 patients), endocervical adenocarcinoma in situ (1 patient), and invasive adenocarcinoma (3 patients). On follow-up, the CB-AGC group was found to have a significantly lower rate of negative/low-grade squamous intraepithelial lesion diagnoses compared with the TP-AGC group (55% vs 85%; P = .006). The CB-AGC group had a significantly higher rate of endocervical or endometrial adenocarcinoma compared with the TP-AGC group (36% vs 8%; P = .003) at the time of follow-up. The rates of high-grade squamous intraepithelial lesion were not found to be statistically different between these 2 groups (9% vs 7%; P = .66).</p> <p>CONCLUSIONS: The Cellient CB is a useful technique to further categorize a diagnosis of AGC on Pap tests. Using the Cellient CB system, the pathologist has the ability to improve the diagnostic accuracy of AGC so that unnecessary colposcopic evaluation or biopsies can be avoided.</p>
dc.identifier.submissionpathfaculty_pubs/503
dc.contributor.departmentDepartment of Pathology
dc.source.pages8-14


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