Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation
UMass Chan Affiliations
Department of Medicine, Division of GastroenterologyDocument Type
Journal ArticlePublication Date
2013-12-01Keywords
Animals*DNA Damage
Endoplasmic Reticulum Stress
Heat-Shock Response
Humans
*Immunity, Innate
Inflammation
Signal Transduction
Cellular and Molecular Physiology
Immunity
Metadata
Show full item recordAbstract
Extensive research in the past decade has identified innate immune recognition receptors and intracellular signaling pathways that culminate in inflammatory responses. Besides its role in cytoprotection, the importance of cell stress in inflammation and host defense against pathogens is emerging. Recent studies have shown that proteins in cellular stress responses, including the heat shock response, ER stress response, and DNA damage response, interact with and regulate signaling intermediates involved in the activation of innate and adaptive immune responses. The effect of such regulation by cell stress proteins may dictate the inflammatory profile of the immune response during infection and disease. In this review, we describe the regulation of innate immune cell activation by cell stress pathways, present detailed descriptions of the types of stress response proteins and their crosstalk with immune signaling intermediates that are essential in host defense, and illustrate the relevance of these interactions in diseases characteristic of aberrant immune responses, such as chronic inflammatory diseases, autoimmune disorders, and cancer. Understanding the crosstalk between cellular stress proteins and immune signaling may have translational implications for designing more effective regimens to treat immune disorders.Source
J Leukoc Biol. 2013 Dec;94(6):1167-84. doi: 10.1189/jlb.0313153. Epub 2013 Aug 29. Link to article on publisher's siteDOI
10.1189/jlb.0313153Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30254PubMed ID
23990626Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1189/jlb.0313153