Central respiratory failure during acute organophosphate poisoning
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Document Type
Journal ArticlePublication Date
2013-11-01Keywords
Acute DiseaseAnimals
Humans
Nerve Net
Organophosphate Poisoning
Organophosphorus Compounds
Respiratory Center
Respiratory Insufficiency
Circulatory and Respiratory Physiology
Emergency Medicine
Medical Physiology
Medical Toxicology
Neurology
Respiratory System
Respiratory Tract Diseases
Toxicology
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Show full item recordAbstract
Organophosphate (OP) pesticide poisoning is a global health problem with over 250,000 deaths per year. OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Mortality due to OP agents is attributed to respiratory dysfunction, including central apnea. Cholinergic circuits are integral to many aspects of the central control of respiration, however it is unclear which mechanisms predominate during acute OP intoxication. A more complete understanding of the cholinergic aspects of both respiratory control as well as neural modification of pulmonary function is needed to better understand OP-induced respiratory dysfunction. In this article, we review the physiologic mechanisms of acute OP exposure in the context of the known cholinergic contributions to the central control of respiration. We also discuss the potential central cholinergic contributions to the known peripheral physiologic effects of OP intoxication.Source
Respir Physiol Neurobiol. 2013 Nov 1;189(2):403-10. doi: 10.1016/j.resp.2013.07.022. Epub 2013 Aug 7. Link to article on publisher's siteDOI
10.1016/j.resp.2013.07.022Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30259PubMed ID
23933009Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.resp.2013.07.022
Scopus Count
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