Obesity Notches up fatty liver

Authors
Czech, Michael P.
UMass Chan Affiliations
Program in Molecular Medicine
Document Type
Journal Article
Publication Date
2013-08-06
Keywords
Animals
Humans
*Lipid Metabolism
Male
Multiprotein Complexes
Proto-Oncogene Proteins c-akt
Receptors, Notch
TOR Serine-Threonine Kinases
Endocrine System Diseases
Endocrinology, Diabetes, and Metabolism

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Link to Full Text
http://dx.doi.org/10.1038/nm.3293
Abstract
Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases.
Source
Nat Med. 2013 Aug;19(8):969-71. doi: 10.1038/nm.3293. Link to article on publisher's site
DOI
10.1038/nm.3293
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30288
PubMed ID
23921741
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