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dc.contributor.authorCzech, Michael P.
dc.date2022-08-11T08:08:31.000
dc.date.accessioned2022-08-23T15:57:49Z
dc.date.available2022-08-23T15:57:49Z
dc.date.issued2013-08-06
dc.date.submitted2015-01-15
dc.identifier.citationNat Med. 2013 Aug;19(8):969-71. doi: 10.1038/nm.3293. <a href="http://dx.doi.org/10.1038/nm.3293">Link to article on publisher's site</a>
dc.identifier.issn1078-8956 (Linking)
dc.identifier.doi10.1038/nm.3293
dc.identifier.pmid23921741
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30288
dc.description.abstractPathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23921741&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/nm.3293
dc.subjectAnimals
dc.subjectHumans
dc.subject*Lipid Metabolism
dc.subjectMale
dc.subjectMultiprotein Complexes
dc.subjectProto-Oncogene Proteins c-akt
dc.subjectReceptors, Notch
dc.subjectTOR Serine-Threonine Kinases
dc.subjectEndocrine System Diseases
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectMolecular Biology
dc.titleObesity Notches up fatty liver
dc.typeJournal Article
dc.source.journaltitleNature medicine
dc.source.volume19
dc.source.issue8
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/540
dc.identifier.contextkey6532268
html.description.abstract<p>Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases.</p>
dc.identifier.submissionpathfaculty_pubs/540
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages969-71


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