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    Detection of immune suppressive neutrophils in peripheral blood samples of cancer patients

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    Authors
    Hao, Suyang
    Andersen, Mary
    Yu, Hongbo
    UMass Chan Affiliations
    Department of Pathology
    Document Type
    Journal Article
    Publication Date
    2013-08-30
    Keywords
    CD62L
    Neutrophils
    cancer
    immunosuppressive
    Allergy and Immunology
    Cells
    Hematology
    Hemic and Immune Systems
    Hemic and Lymphatic Diseases
    Immunity
    Immunopathology
    Immunoprophylaxis and Therapy
    Neoplasms
    Pathology
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    Abstract
    Neutrophils provide first-line defense against infections and are potent effectors in innate and adaptive immunity. Recently neutrophils have been shown to play important roles in multiple antitumor reactions. A subset of mature neutrophils in human systemic inflammation has been identified as a unique circulating population of myeloid cells, which is capable of inhibiting T cell responses. These neutrophils show unique immunophenotype (CD11c bright/CD62L dim/CD11b bright/CD16 bright). This study reports detection of mature neutrophils with similar immunophenotype in the peripheral blood samples of cancer patients using flow cytometry analysis. This population of neutrophils is not detected in peripheral blood samples of normal controls. Thus this finding suggests the involvement of mature neutrophils in antitumor immunity.
    Source
    Am J Blood Res. 2013 Aug 19;3(3):239-45. eCollection 2013. Link to article on publisher's website
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30290
    PubMed ID
    23997986
    Related Resources
    Link to Article in PubMed
    Rights
    Paper released under the Creative Commons Attribution Noncommercial License as stated by the publisher's author rights policy at http://www.ajblood.us/Instruction.html.
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    UMass Chan Faculty and Researcher Publications

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