Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence
AuthorsJandhyala, Dakshina M.
Vanguri, Vijay K.
Boll, Erik J.
Lai, YuShuan (Cindy)
McCormick, Beth A.
Leong, John M.
UMass Chan AffiliationsDepartment of Pathology
Department of Microbiology and Physiological Systems
Document TypeJournal Article
KeywordsCommunicable Diseases, Emerging
Escherichia coli Infections
Shiga-Toxigenic Escherichia coli
Digestive System Diseases
Immunology and Infectious Disease
MetadataShow full item record
AbstractPathogenic Escherichia coli are genetically diverse and encompass a broad variety of pathotypes, such as enteroaggregative E. coli (EAEC) or enterohemorrhagic E. coli (EHEC), which cause distinct clinical syndromes. The historically large 2011 German outbreak of hemolytic uremic syndrome (HUS), caused by a Shiga-toxin producing E. coli (STEC) of the serotype O104:H4, illustrated the emerging importance of non-O157 STEC. STEC O104:H4, with features characteristic of both enteroaggregative E. coli and enterohemorrhagic E. coli, represents a unique and highly virulent pathotype. The German outbreak both allowed for the evaluation of several potential therapeutic approaches to STEC-induced HUS and emphasizes the importance of early and specific detection of both O157 and non-O157 STEC.
SourceInfect Dis Clin North Am. 2013 Sep;27(3):631-49. doi: 10.1016/j.idc.2013.05.002. Epub 2013 Jul 24. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/30313
Related ResourcesLink to Article in PubMed