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Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence

dc.contributor.authorJandhyala, Dakshina M.
dc.contributor.authorVanguri, Vijay K.
dc.contributor.authorBoll, Erik J.
dc.contributor.authorLai, YuShuan (Cindy)
dc.contributor.authorMcCormick, Beth A.
dc.contributor.authorLeong, John M.
dc.date2022-08-11T08:08:31.000
dc.date.accessioned2022-08-23T15:57:55Z
dc.date.available2022-08-23T15:57:55Z
dc.date.issued2013-09-10
dc.date.submitted2015-03-24
dc.identifier.citationInfect Dis Clin North Am. 2013 Sep;27(3):631-49. doi: 10.1016/j.idc.2013.05.002. Epub 2013 Jul 24. <a href="http://dx.doi.org/10.1016/j.idc.2013.05.002">Link to article on publisher's site</a>
dc.identifier.issn0891-5520 (Linking)
dc.identifier.doi10.1016/j.idc.2013.05.002
dc.identifier.pmid24011834
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30313
dc.description.abstractPathogenic Escherichia coli are genetically diverse and encompass a broad variety of pathotypes, such as enteroaggregative E. coli (EAEC) or enterohemorrhagic E. coli (EHEC), which cause distinct clinical syndromes. The historically large 2011 German outbreak of hemolytic uremic syndrome (HUS), caused by a Shiga-toxin producing E. coli (STEC) of the serotype O104:H4, illustrated the emerging importance of non-O157 STEC. STEC O104:H4, with features characteristic of both enteroaggregative E. coli and enterohemorrhagic E. coli, represents a unique and highly virulent pathotype. The German outbreak both allowed for the evaluation of several potential therapeutic approaches to STEC-induced HUS and emphasizes the importance of early and specific detection of both O157 and non-O157 STEC.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24011834&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800737/
dc.subjectCommunicable Diseases, Emerging
dc.subjectDisease Outbreaks
dc.subjectEscherichia coli Infections
dc.subjectEurope
dc.subjectGenome, Bacterial
dc.subjectHumans
dc.subjectShiga-Toxigenic Escherichia coli
dc.subjectVirulence
dc.subjectBacteria
dc.subjectDigestive System Diseases
dc.subjectImmunology and Infectious Disease
dc.subjectMicrobiology
dc.subjectPathogenic Microbiology
dc.titleShiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence
dc.typeJournal Article
dc.source.journaltitleInfectious disease clinics of North America
dc.source.volume27
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/575
dc.identifier.contextkey6889239
html.description.abstract<p>Pathogenic Escherichia coli are genetically diverse and encompass a broad variety of pathotypes, such as enteroaggregative E. coli (EAEC) or enterohemorrhagic E. coli (EHEC), which cause distinct clinical syndromes. The historically large 2011 German outbreak of hemolytic uremic syndrome (HUS), caused by a Shiga-toxin producing E. coli (STEC) of the serotype O104:H4, illustrated the emerging importance of non-O157 STEC. STEC O104:H4, with features characteristic of both enteroaggregative E. coli and enterohemorrhagic E. coli, represents a unique and highly virulent pathotype. The German outbreak both allowed for the evaluation of several potential therapeutic approaches to STEC-induced HUS and emphasizes the importance of early and specific detection of both O157 and non-O157 STEC.</p>
dc.identifier.submissionpathfaculty_pubs/575
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.source.pages631-49


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