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dc.contributor.authorMajid, Adnan
dc.contributor.authorSosa, Andres F.
dc.contributor.authorErnst, Armin
dc.contributor.authorFeller-Kopman, David
dc.contributor.authorFolch, Erik
dc.contributor.authorSingh, Anup K.
dc.contributor.authorGangadharan, Sidhu
dc.date2022-08-11T08:08:31.000
dc.date.accessioned2022-08-23T15:57:57Z
dc.date.available2022-08-23T15:57:57Z
dc.date.issued2013-09-01
dc.date.submitted2015-03-24
dc.identifier.citationRespir Care. 2013 Sep;58(9):1521-6. doi: 10.4187/respcare.02277. Epub 2013 Mar 12. <a href="http://dx.doi.org/10.4187/respcare.02277">Link to article on publisher's site</a>
dc.identifier.issn0020-1324 (Linking)
dc.identifier.doi10.4187/respcare.02277
dc.identifier.pmid24493684
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30319
dc.description.abstractBACKGROUND: Patterns of pulmonary function tests (PFTs) and flow-volume loops among patients with clinically important tracheobronchomalacia (TBM) are not well described. Small studies suggest 4 main flow-volume loop morphologies: low maximum forced expiratory flow, biphasic expiratory curve, flow oscillations, and notching. We studied common PFT and flow-volume loop patterns among the largest prospective series of patients to date, undergoing clinical evaluation for symptomatic moderate to severe TBM. METHODS: We conducted a retrospective analysis of prospectively collected data from patients who were referred to our Chest Disease Center from January 2002 to December 2008, with respiratory symptoms that were attributed primarily to TBM. The PFT results of 90 subjects with symptomatic moderate to severe TBM were evaluated. RESULTS: By PFTs, 40 (44.4%) subjects had an obstructive ventilatory defect, 16 (17.8%) had a definite or highly likely restrictive ventilatory defect, 15 (16.7%) had a mixed defect, and 19 (21.1%) were within normal limits. Among 76 subjects with available flow-volume loops, the most frequent finding was low maximum forced expiratory flow, in 62 (81.6%) subjects, followed by biphasic morphology (15, 19.7%), notched expiratory loop (7, 9.2%), and expiratory oscillations (2, 2.6%). The balance of 13 subjects (17.1%) had no distinctive flow-volume loop abnormality. CONCLUSION: PFTs and flow-volume loops are normal in a substantial number of patients with moderate to severe TBM, and should not be used to decide whether TBM is present or clinically important.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24493684&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.4187/respcare.02277
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subject*Respiratory Function Tests
dc.subjectTracheobronchomalacia
dc.subjectDiagnosis
dc.subjectRespiratory Tract Diseases
dc.titlePulmonary function and flow-volume loop patterns in patients with tracheobronchomalacia
dc.typeJournal Article
dc.source.journaltitleRespiratory care
dc.source.volume58
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/586
dc.identifier.contextkey6889251
html.description.abstract<p><h4>BACKGROUND:</h4></p> <p>Patterns of pulmonary function tests (PFTs) and flow-volume loops among patients with clinically important tracheobronchomalacia (TBM) are not well described. Small studies suggest 4 main flow-volume loop morphologies: low maximum forced expiratory flow, biphasic expiratory curve, flow oscillations, and notching. We studied common PFT and flow-volume loop patterns among the largest prospective series of patients to date, undergoing clinical evaluation for symptomatic moderate to severe TBM. <h4>METHODS:</h4></p> <p>We conducted a retrospective analysis of prospectively collected data from patients who were referred to our Chest Disease Center from January 2002 to December 2008, with respiratory symptoms that were attributed primarily to TBM. The PFT results of 90 subjects with symptomatic moderate to severe TBM were evaluated. <h4>RESULTS:</h4></p> <p>By PFTs, 40 (44.4%) subjects had an obstructive ventilatory defect, 16 (17.8%) had a definite or highly likely restrictive ventilatory defect, 15 (16.7%) had a mixed defect, and 19 (21.1%) were within normal limits. Among 76 subjects with available flow-volume loops, the most frequent finding was low maximum forced expiratory flow, in 62 (81.6%) subjects, followed by biphasic morphology (15, 19.7%), notched expiratory loop (7, 9.2%), and expiratory oscillations (2, 2.6%). The balance of 13 subjects (17.1%) had no distinctive flow-volume loop abnormality. <h4>CONCLUSION:</h4></p> <p>PFTs and flow-volume loops are normal in a substantial number of patients with moderate to severe TBM, and should not be used to decide whether TBM is present or clinically important.</p>
dc.identifier.submissionpathfaculty_pubs/586
dc.contributor.departmentDepartment of Medicine, Division of Pulmonary, Allergy & Critical Care
dc.source.pages1521-6


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