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    Metastatic carcinoma to the thyroid gland: a single institution 20-year experience and review of the literature

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    Authors
    Moghaddam, Parnian Ahmadi
    Cornejo, Kristine M.
    Khan, Ashraf
    UMass Chan Affiliations
    Department of Pathology
    Document Type
    Journal Article
    Publication Date
    2013-09-01
    Keywords
    Adult
    Aged
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    Female
    Humans
    Lung Neoplasms
    Male
    Mesothelioma
    Middle Aged
    Retrospective Studies
    Thyroid Neoplasms
    Endocrine System
    Endocrine System Diseases
    Neoplasms
    Pathology
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    Link to Full Text
    http://dx.doi.org/10.1007/s12022-013-9257-8
    Abstract
    The thyroid gland is an uncommon site for metastatic disease but cases have been well-documented in the literature, particularly in autopsy series. A retrospective review of surgical pathology and autopsy pathology database for patients with metastatic carcinoma to the thyroid was performed at the University of Massachusetts Medical Center between January 1993 to January 2013. We identified a total of 10 patients with metastatic carcinoma to the thyroid; 6 were in surgical pathology specimens out of a total of 1,295 thyroid carcinoma (0.46 %) and 4 were diagnosed at autopsy out of a total of 2,117 (0.19 %) autopsy cases during this period. Cases with direct extension of the tumor into the thyroid from local primary sites such as larynx, esophagus or soft tissues of the neck were excluded. The primary tumors in these cases comprised of four lung carcinomas, three colorectal carcinomas, a renal cell carcinoma, a pleural malignant mesothelioma, and an unknown primary. Therefore, it is important to keep intrathyroidal metastases in the differential diagnosis when evaluating a thyroid nodule, particularly in patients with a previous history of malignancy. Furthermore, a literature review reveals over 1,400 cases have been previously reported, with the most common malignancies from the kidney (34 %), lung (15 %), gastrointestinal tract (14 %), and breast (14 %).
    Source
    Endocr Pathol. 2013 Sep;24(3):116-24. doi: 10.1007/s12022-013-9257-8. Link to article on publisher's site
    DOI
    10.1007/s12022-013-9257-8
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30320
    PubMed ID
    23872914
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12022-013-9257-8
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      The effect of radiation timing on patients with high-risk features of parameningeal rhabdomyosarcoma: an analysis of IRS-IV and D9803

      Spalding, Aaron C.; Hawkins, Douglas S.; Donaldson, Sarah S.; Anderson, James R.; Lyden, Elizabeth R.; Laurie, Fran; Wolden, Suzanne; Arndt, Carola; Michalski, Jeff M. (2013-11-01)
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