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Delineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography

dc.contributor.authorPatel, Rakesh
dc.contributor.authorKhan, Ashraf
dc.contributor.authorKamionek, Michal
dc.contributor.authorKandil, Dina H
dc.contributor.authorQuinlan, Robert
dc.contributor.authorYaroslavsky, Anna N.
dc.date2022-08-11T08:08:31.000
dc.date.accessioned2022-08-23T15:57:58Z
dc.date.available2022-08-23T15:57:58Z
dc.date.issued2013-09-01
dc.date.submitted2015-03-24
dc.identifier.citationJ Biophotonics. 2013 Sep;6(9):679-86. doi: 10.1002/jbio.201200102. Epub 2012 Sep 25. <a href="http://dx.doi.org/10.1002/jbio.201200102">Link to article on publisher's site</a>
dc.identifier.issn1864-063X (Linking)
dc.identifier.doi10.1002/jbio.201200102
dc.identifier.pmid23008236
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30323
dc.description.abstractIntra-operative delineation of breast cancer is a challenging problem. We used dye-enhanced wide-field polarization imaging for rapid demarcation of en face cancer margins and optical coherence tomography (OCT) for cross-sectional evaluation. Ductal carcinoma specimens were stained with methylene blue. Wide-field reflectance images were acquired at 440 and 640 nm. Wide-field fluorescence images were excited at 640 nm and registered between 660 nm and 750 nm. OCT images were acquired using a 1310 nm swept-source system. The results were validated against histopathology. Both imaging modalities provided diagnostic information on cancer margins. Combined OCT and wide-field polarization imaging shows promise for intra-operative detection of ductal breast carcinoma.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23008236&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/jbio.201200102
dc.subjectAdult
dc.subjectAged
dc.subjectCarcinoma, Ductal, Breast
dc.subjectColoring Agents
dc.subjectFemale
dc.subjectHumans
dc.subjectIntraoperative Period
dc.subjectMiddle Aged
dc.subject*Molecular Imaging
dc.subject*Tomography, Optical Coherence
dc.subjectInvestigative Techniques
dc.subjectMedical Biophysics
dc.subjectNeoplasms
dc.subjectPathology
dc.titleDelineating breast ductal carcinoma using combined dye-enhanced wide-field polarization imaging and optical coherence tomography
dc.typeJournal Article
dc.source.journaltitleJournal of biophotonics
dc.source.volume6
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/593
dc.identifier.contextkey6889259
html.description.abstract<p>Intra-operative delineation of breast cancer is a challenging problem. We used dye-enhanced wide-field polarization imaging for rapid demarcation of en face cancer margins and optical coherence tomography (OCT) for cross-sectional evaluation. Ductal carcinoma specimens were stained with methylene blue. Wide-field reflectance images were acquired at 440 and 640 nm. Wide-field fluorescence images were excited at 640 nm and registered between 660 nm and 750 nm. OCT images were acquired using a 1310 nm swept-source system. The results were validated against histopathology. Both imaging modalities provided diagnostic information on cancer margins. Combined OCT and wide-field polarization imaging shows promise for intra-operative detection of ductal breast carcinoma.</p>
dc.identifier.submissionpathfaculty_pubs/593
dc.contributor.departmentDepartment of Pathology
dc.source.pages679-86


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