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dc.contributor.authorPerisse, Emmanuel
dc.contributor.authorYin, Yan
dc.contributor.authorLin, Andrew C.
dc.contributor.authorLin, Suewei
dc.contributor.authorHuetteroth, Wolf
dc.contributor.authorWaddell, Scott
dc.date2022-08-11T08:08:31.000
dc.date.accessioned2022-08-23T15:57:58Z
dc.date.available2022-08-23T15:57:58Z
dc.date.issued2013-09-04
dc.date.submitted2015-03-24
dc.identifier.citationNeuron. 2013 Sep 4;79(5):945-56. doi: 10.1016/j.neuron.2013.07.045. <a href="http://dx.doi.org/10.1016/j.neuron.2013.07.045">Link to article on publisher's site</a>
dc.identifier.issn0896-6273 (Linking)
dc.identifier.doi10.1016/j.neuron.2013.07.045
dc.identifier.pmid24012007
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30325
dc.description.abstractIn Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the alphabeta neurons, revealing a value-specific role for the approximately 160 alphabeta core (alphabetac) neurons. Blocking neurotransmission from alphabeta surface (alphabetas) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking alphabetac only impaired appetitive memory. The alphabetac were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate alphabetac and alphabetas in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the alphabeta ensemble but only from the alphabetas for conditioned aversion.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24012007&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.neuron.2013.07.045
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectAnimals
dc.subjectAppetitive Behavior
dc.subjectAvoidance Learning
dc.subjectBehavior, Animal
dc.subjectDopaminergic Neurons
dc.subjectDrosophila
dc.subjectLearning
dc.subjectMemory
dc.subjectMushroom Bodies
dc.subjectSmell
dc.subjectDrosophila melanogaster
dc.subjectMemory
dc.subjectSmell
dc.subjectLearning
dc.subjectBehavioral Neurobiology
dc.subjectMolecular and Cellular Neuroscience
dc.titleDifferent kenyon cell populations drive learned approach and avoidance in Drosophila
dc.typeJournal Article
dc.source.journaltitleNeuron
dc.source.volume79
dc.source.issue5
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1594&amp;context=faculty_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/595
dc.identifier.contextkey6889261
refterms.dateFOA2022-08-23T15:57:58Z
html.description.abstract<p>In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the alphabeta neurons, revealing a value-specific role for the approximately 160 alphabeta core (alphabetac) neurons. Blocking neurotransmission from alphabeta surface (alphabetas) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking alphabetac only impaired appetitive memory. The alphabetac were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate alphabetac and alphabetas in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the alphabeta ensemble but only from the alphabetas for conditioned aversion.</p>
dc.identifier.submissionpathfaculty_pubs/595
dc.contributor.departmentWaddell Lab
dc.contributor.departmentNeurobiology
dc.source.pages945-56
dc.contributor.studentSuewei Lin
dc.description.thesisprogramNeuroscience


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