Show simple item record

dc.contributor.authorFisher, Kimberly A.
dc.contributor.authorStefan, Mihaela S.
dc.contributor.authorDarling, Chad E.
dc.contributor.authorLessard, Darleen M.
dc.contributor.authorGoldberg, Robert J.
dc.date2022-08-11T08:08:32.000
dc.date.accessioned2022-08-23T15:58:15Z
dc.date.available2022-08-23T15:58:15Z
dc.date.issued2015-03-01
dc.date.submitted2015-06-17
dc.identifier.citationChest. 2015 Mar;147(3):637-45. doi: 10.1378/chest.14-0607. <a href="http://dx.doi.org/10.1378/chest.14-0607">Link to article on publisher's site</a>
dc.identifier.issn0012-3692 (Linking)
dc.identifier.doi10.1378/chest.14-0607
dc.identifier.pmid25188234
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30390
dc.description.abstractBACKGROUND: COPD is a common comorbidity in patients with heart failure, yet little is known about the impact of this condition in patients with acute decompensated heart failure (ADHF), especially from a more generalizable, community-based perspective. The primary objective of this study was to describe the in-hospital and postdischarge mortality and treatment of patients hospitalized with ADHF according to COPD status. METHODS: The study population consisted of patients hospitalized with ADHF at all 11 medical centers in central Massachusetts during four study years: 1995, 2000, 2002, and 2004. Patients were followed through 2010 for determination of their vital status. RESULTS: Of the 9,748 patients hospitalized with ADHF during the years under study, 35.9% had a history of COPD. The average age of this population was 76.1 years, 43.9% were men, and 93.3% were white. At the time of hospital discharge, patients with COPD were less likely to have received evidence-based heart failure medications, including beta-blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, than patients without COPD. Multivariable, adjusted in-hospital death rates were similar for patients with and without COPD. However, among patients who survived to hospital discharge, patients with COPD had a significantly higher risk of dying at 1 year (adjusted relative risk [RR], 1.10; 95% CI, 1.06-1.14) and 5 years (adjusted RR, 1.40; 95% CI, 1.28-1.52) after hospital discharge than patients who were not previously diagnosed with COPD. CONCLUSIONS: COPD is a common comorbidity in patients hospitalized with ADHF and is associated with a worse long-term prognosis. Further research is required to understand the complex interactions of these diseases and ensure that patients with ADHF and COPD receive optimal treatment modalities.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25188234&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1378/chest.14-0607
dc.subjectAcute Disease
dc.subjectAdrenergic beta-Antagonists
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectComorbidity
dc.subjectFemale
dc.subjectHeart Failure
dc.subject*Hospital Mortality
dc.subjectHumans
dc.subject*Inpatients
dc.subjectMale
dc.subjectMassachusetts
dc.subjectOutpatients
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.subjectTreatment Outcome
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectClinical Epidemiology
dc.subjectEpidemiology
dc.subjectRespiratory Tract Diseases
dc.titleImpact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study
dc.typeJournal Article
dc.source.journaltitleChest
dc.source.volume147
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/664
dc.identifier.contextkey7227770
html.description.abstract<p>BACKGROUND: COPD is a common comorbidity in patients with heart failure, yet little is known about the impact of this condition in patients with acute decompensated heart failure (ADHF), especially from a more generalizable, community-based perspective. The primary objective of this study was to describe the in-hospital and postdischarge mortality and treatment of patients hospitalized with ADHF according to COPD status.</p> <p>METHODS: The study population consisted of patients hospitalized with ADHF at all 11 medical centers in central Massachusetts during four study years: 1995, 2000, 2002, and 2004. Patients were followed through 2010 for determination of their vital status.</p> <p>RESULTS: Of the 9,748 patients hospitalized with ADHF during the years under study, 35.9% had a history of COPD. The average age of this population was 76.1 years, 43.9% were men, and 93.3% were white. At the time of hospital discharge, patients with COPD were less likely to have received evidence-based heart failure medications, including beta-blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, than patients without COPD. Multivariable, adjusted in-hospital death rates were similar for patients with and without COPD. However, among patients who survived to hospital discharge, patients with COPD had a significantly higher risk of dying at 1 year (adjusted relative risk [RR], 1.10; 95% CI, 1.06-1.14) and 5 years (adjusted RR, 1.40; 95% CI, 1.28-1.52) after hospital discharge than patients who were not previously diagnosed with COPD.</p> <p>CONCLUSIONS: COPD is a common comorbidity in patients hospitalized with ADHF and is associated with a worse long-term prognosis. Further research is required to understand the complex interactions of these diseases and ensure that patients with ADHF and COPD receive optimal treatment modalities.</p>
dc.identifier.submissionpathfaculty_pubs/664
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Emergency Medicine
dc.contributor.departmentDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine
dc.source.pages637-45


This item appears in the following Collection(s)

Show simple item record