Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study
dc.contributor.author | Fisher, Kimberly A. | |
dc.contributor.author | Stefan, Mihaela S. | |
dc.contributor.author | Darling, Chad E. | |
dc.contributor.author | Lessard, Darleen M. | |
dc.contributor.author | Goldberg, Robert J. | |
dc.date | 2022-08-11T08:08:32.000 | |
dc.date.accessioned | 2022-08-23T15:58:15Z | |
dc.date.available | 2022-08-23T15:58:15Z | |
dc.date.issued | 2015-03-01 | |
dc.date.submitted | 2015-06-17 | |
dc.identifier.citation | Chest. 2015 Mar;147(3):637-45. doi: 10.1378/chest.14-0607. <a href="http://dx.doi.org/10.1378/chest.14-0607">Link to article on publisher's site</a> | |
dc.identifier.issn | 0012-3692 (Linking) | |
dc.identifier.doi | 10.1378/chest.14-0607 | |
dc.identifier.pmid | 25188234 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/30390 | |
dc.description.abstract | BACKGROUND: COPD is a common comorbidity in patients with heart failure, yet little is known about the impact of this condition in patients with acute decompensated heart failure (ADHF), especially from a more generalizable, community-based perspective. The primary objective of this study was to describe the in-hospital and postdischarge mortality and treatment of patients hospitalized with ADHF according to COPD status. METHODS: The study population consisted of patients hospitalized with ADHF at all 11 medical centers in central Massachusetts during four study years: 1995, 2000, 2002, and 2004. Patients were followed through 2010 for determination of their vital status. RESULTS: Of the 9,748 patients hospitalized with ADHF during the years under study, 35.9% had a history of COPD. The average age of this population was 76.1 years, 43.9% were men, and 93.3% were white. At the time of hospital discharge, patients with COPD were less likely to have received evidence-based heart failure medications, including beta-blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, than patients without COPD. Multivariable, adjusted in-hospital death rates were similar for patients with and without COPD. However, among patients who survived to hospital discharge, patients with COPD had a significantly higher risk of dying at 1 year (adjusted relative risk [RR], 1.10; 95% CI, 1.06-1.14) and 5 years (adjusted RR, 1.40; 95% CI, 1.28-1.52) after hospital discharge than patients who were not previously diagnosed with COPD. CONCLUSIONS: COPD is a common comorbidity in patients hospitalized with ADHF and is associated with a worse long-term prognosis. Further research is required to understand the complex interactions of these diseases and ensure that patients with ADHF and COPD receive optimal treatment modalities. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25188234&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1378/chest.14-0607 | |
dc.subject | Acute Disease | |
dc.subject | Adrenergic beta-Antagonists | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Angiotensin-Converting Enzyme Inhibitors | |
dc.subject | Comorbidity | |
dc.subject | Female | |
dc.subject | Heart Failure | |
dc.subject | *Hospital Mortality | |
dc.subject | Humans | |
dc.subject | *Inpatients | |
dc.subject | Male | |
dc.subject | Massachusetts | |
dc.subject | Outpatients | |
dc.subject | Pulmonary Disease, Chronic Obstructive | |
dc.subject | Retrospective Studies | |
dc.subject | Survival Rate | |
dc.subject | Treatment Outcome | |
dc.subject | Cardiology | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Clinical Epidemiology | |
dc.subject | Epidemiology | |
dc.subject | Respiratory Tract Diseases | |
dc.title | Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study | |
dc.type | Journal Article | |
dc.source.journaltitle | Chest | |
dc.source.volume | 147 | |
dc.source.issue | 3 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/664 | |
dc.identifier.contextkey | 7227770 | |
html.description.abstract | <p>BACKGROUND: COPD is a common comorbidity in patients with heart failure, yet little is known about the impact of this condition in patients with acute decompensated heart failure (ADHF), especially from a more generalizable, community-based perspective. The primary objective of this study was to describe the in-hospital and postdischarge mortality and treatment of patients hospitalized with ADHF according to COPD status.</p> <p>METHODS: The study population consisted of patients hospitalized with ADHF at all 11 medical centers in central Massachusetts during four study years: 1995, 2000, 2002, and 2004. Patients were followed through 2010 for determination of their vital status.</p> <p>RESULTS: Of the 9,748 patients hospitalized with ADHF during the years under study, 35.9% had a history of COPD. The average age of this population was 76.1 years, 43.9% were men, and 93.3% were white. At the time of hospital discharge, patients with COPD were less likely to have received evidence-based heart failure medications, including beta-blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, than patients without COPD. Multivariable, adjusted in-hospital death rates were similar for patients with and without COPD. However, among patients who survived to hospital discharge, patients with COPD had a significantly higher risk of dying at 1 year (adjusted relative risk [RR], 1.10; 95% CI, 1.06-1.14) and 5 years (adjusted RR, 1.40; 95% CI, 1.28-1.52) after hospital discharge than patients who were not previously diagnosed with COPD.</p> <p>CONCLUSIONS: COPD is a common comorbidity in patients hospitalized with ADHF and is associated with a worse long-term prognosis. Further research is required to understand the complex interactions of these diseases and ensure that patients with ADHF and COPD receive optimal treatment modalities.</p> | |
dc.identifier.submissionpath | faculty_pubs/664 | |
dc.contributor.department | Department of Quantitative Health Sciences | |
dc.contributor.department | Department of Emergency Medicine | |
dc.contributor.department | Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine | |
dc.source.pages | 637-45 |