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dc.contributor.authorNeavyn, Mark
dc.contributor.authorBoyer, Edward W.
dc.contributor.authorBird, Steven B.
dc.contributor.authorBabu, Kavita
dc.date2022-08-11T08:08:32.000
dc.date.accessioned2022-08-23T15:58:18Z
dc.date.available2022-08-23T15:58:18Z
dc.date.issued2013-04-30
dc.date.submitted2013-06-18
dc.identifier.citationJ Med Toxicol. 2013 Apr 30. <a href="http://dx.doi.org/10.1007/s13181-013-0304-0">Link to article on publisher's site</a>
dc.identifier.issn1556-9039 (Linking)
dc.identifier.doi10.1007/s13181-013-0304-0
dc.identifier.pmid23636658
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30403
dc.description.abstractSodium bicarbonate is central to the treatment of many poisonings. When it was placed on the FDA drug shortage list in 2012, alternative treatment strategies to specific poisonings were considered. Many hospital pharmacies, poison centers, and medical toxicologists proposed sodium acetate as an adequate alternative, despite a paucity of data to support its use in medical toxicology. The intention of this review is to educate the clinician on the use of sodium acetate and to advise them on the potential adverse events when given in excess. We conducted a literature search focused on the pharmacology of sodium acetate, its use as a buffer in pathologic acidemia and dialysis baths, and potential adverse events associated with excess sodium acetate infusion. It appears safe to replace sodium bicarbonate infusion with sodium acetate on an equimolar basis. The metabolism of acetate, however, is more complex than bicarbonate. Future prospective studies will be needed to confirm the efficacy of sodium acetate in the treatment of the poisoned patient.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23636658&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1007/s13181-013-0304-0
dc.subjectSodium Acetate
dc.subjectSodium Bicarbonate
dc.subjectAntidotes
dc.subjectEmergency Medicine
dc.subjectMedical Toxicology
dc.titleSodium Acetate as a Replacement for Sodium Bicarbonate in Medical Toxicology: a Review
dc.typeJournal Article
dc.source.journaltitleJournal of medical toxicology : official journal of the American College of Medical Toxicology
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/68
dc.identifier.contextkey4236700
html.description.abstract<p>Sodium bicarbonate is central to the treatment of many poisonings. When it was placed on the FDA drug shortage list in 2012, alternative treatment strategies to specific poisonings were considered. Many hospital pharmacies, poison centers, and medical toxicologists proposed sodium acetate as an adequate alternative, despite a paucity of data to support its use in medical toxicology. The intention of this review is to educate the clinician on the use of sodium acetate and to advise them on the potential adverse events when given in excess. We conducted a literature search focused on the pharmacology of sodium acetate, its use as a buffer in pathologic acidemia and dialysis baths, and potential adverse events associated with excess sodium acetate infusion. It appears safe to replace sodium bicarbonate infusion with sodium acetate on an equimolar basis. The metabolism of acetate, however, is more complex than bicarbonate. Future prospective studies will be needed to confirm the efficacy of sodium acetate in the treatment of the poisoned patient.</p>
dc.identifier.submissionpathfaculty_pubs/68
dc.contributor.departmentDepartment of Emergency Medicine


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