Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years
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Document Type
Journal ArticlePublication Date
2013-10-30Keywords
Animals*Biological Evolution
Cell Differentiation
History, 20th Century
History, 21st Century
Humans
Neuroglia
Neurosciences
Developmental Neuroscience
Neuroscience and Neurobiology
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Glial cells are present in all organisms with a CNS and, with increasing brain complexity, glial cells have undergone substantive increases in cell number, diversity, and functions. Invertebrates, such as Drosophila, possess glial subtypes with similarity to mammalian astrocytes in their basic morphology and function, representing fertile ground for unraveling fundamental aspects of glial biology. Although glial subtypes in simple organisms may be relatively homogenous, emerging evidence suggests the possibility that mammalian astrocytes might be highly diversified to match the needs of local neuronal subtypes. In this Perspective, we review classic and new roles identified for astrocytes and oligodendrocytes by recent studies. We propose that delineating genetic and developmental programs across species will be essential to understand the core functions of glia that allow enhanced neuronal function and to achieve new insights into glial roles in higher-order brain function and neurological disease.Source
Neuron. 2013 Oct 30;80(3):613-23. doi: 10.1016/j.neuron.2013.10.034. Link to article on publisher's siteDOI
10.1016/j.neuron.2013.10.034Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30480PubMed ID
24183014Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.neuron.2013.10.034