NKp30 enables NK cells to act naturally with fungi

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Authors
Quintin, Jessica
Levitz, Stuart M.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Disease & Immunology
Document Type
Journal Article
Publication Date
2013-10-16
Keywords
Candida
Cryptococcus
HIV Infections
*Host-Pathogen Interactions
Humans
*Immune Tolerance
Killer Cells, Natural
Natural Cytotoxicity Triggering Receptor 3
Immunology of Infectious Disease

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Link to Full Text
http://dx.doi.org/10.1016/j.chom.2013.10.001
Abstract
NK cells have direct activity against fungal pathogens. Using an unbiased systematic approach, Li et al. (2013) find that NKp30 is a major NK cell receptor responsible for fungal recognition. Moreover, diminished NKp30 expression is associated with reduced antifungal activity in NK cells isolated from HIV-infected persons.
Source
Cell Host Microbe. 2013 Oct 16;14(4):369-71. doi: 10.1016/j.chom.2013.10.001. Link to article on publisher's site
DOI
10.1016/j.chom.2013.10.001
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30500
PubMed ID
24139394
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