Dicer's role as an antiviral: still an enigma
| dc.contributor.author | MacKay, Christopher R | |
| dc.contributor.author | Wang, Jennifer P. | |
| dc.contributor.author | Kurt-Jones, Evelyn A. | |
| dc.date | 2022-08-11T08:08:33.000 | |
| dc.date.accessioned | 2022-08-23T15:58:49Z | |
| dc.date.available | 2022-08-23T15:58:49Z | |
| dc.date.issued | 2014-02-01 | |
| dc.date.submitted | 2015-11-25 | |
| dc.identifier.citation | Curr Opin Immunol. 2014 Feb;26:49-55. doi: 10.1016/j.coi.2013.10.015. Epub 2013 Nov 22. <a href="http://dx.doi.org/10.1016/j.coi.2013.10.015">Link to article on publisher's site</a> | |
| dc.identifier.issn | 0952-7915 (Linking) | |
| dc.identifier.doi | 10.1016/j.coi.2013.10.015 | |
| dc.identifier.pmid | 24556400 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/30524 | |
| dc.description.abstract | Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral activity occurs via small interfering RNA production following cytoplasmic sensing of viral dsRNA. Notably, such antiviral activity has not yet been clearly demonstrated in higher organisms such as mammals. Here, we review the evidence for Dicer as an innate antiviral across species. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24556400&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932008/ | |
| dc.subject | Animals | |
| dc.subject | Antiviral Agents | |
| dc.subject | Caenorhabditis elegans | |
| dc.subject | DEAD-box RNA Helicases | |
| dc.subject | Drosophila melanogaster | |
| dc.subject | Humans | |
| dc.subject | RNA, Viral | |
| dc.subject | Ribonuclease III | |
| dc.subject | Immunology of Infectious Disease | |
| dc.subject | Immunopathology | |
| dc.subject | Molecular Genetics | |
| dc.subject | Virology | |
| dc.title | Dicer's role as an antiviral: still an enigma | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Current opinion in immunology | |
| dc.source.volume | 26 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/800 | |
| dc.identifier.contextkey | 7880375 | |
| html.description.abstract | <p>Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral activity occurs via small interfering RNA production following cytoplasmic sensing of viral dsRNA. Notably, such antiviral activity has not yet been clearly demonstrated in higher organisms such as mammals. Here, we review the evidence for Dicer as an innate antiviral across species.</p> | |
| dc.identifier.submissionpath | faculty_pubs/800 | |
| dc.contributor.department | Department of Medicine, Division of Infectious Diseases and Immunology | |
| dc.source.pages | 49-55 |
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