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    Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients

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    Authors
    Zacharias, Michael
    Joffe, Samuel
    Konadu, Elizabeth
    Meyer, Theo E.
    Kiernan, MIchael S.
    Lessard, Darleen M.
    Goldberg, Robert J.
    UMass Chan Affiliations
    Department of Quantitative Health Sciences
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2016-01-01
    Keywords
    UMCCTS funding
    Cardiology
    Cardiovascular Diseases
    Clinical Epidemiology
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656064/
    Abstract
    BACKGROUND: While heart failure with preserved ejection fraction (HFpEF) is primarily a disease of old age, risk factors that contribute to HFpEF are not limited to older patients. The objectives of this population-based observational study were to describe the clinical epidemiology of HFpEF in younger ( < 65years) as compared with older ( > /=65years) patients hospitalized with acute decompensated heart failure. METHODS AND RESULTS: We reviewed the medical records of residents of central Massachusetts hospitalized with HFpEF at all 11 greater Worcester (MA) medical centers during the 5 study years of 1995, 2000, 2002, 2004, and 2006. Among the 2398 patients hospitalized with confirmed HFpEF, 357 (14.9%) were < 65years old. Younger patients were more likely to be male, non-Caucasian, obese, and to have a history of diabetes and chronic kidney disease than older patients with HFpEF. Younger patients hospitalized with HFpEF were less likely to have received commonly prescribed cardiac medications, had a longer hospital stay, and experienced significantly lower post-discharge death rates than older hospitalized patients. CONCLUSION: While HFpEF is predominantly a disease of old age, data from longitudinal studies remain needed to identify risk factors in younger individuals that may predispose them to the development of HFpEF.
    Source

    Int J Cardiol. 2016 Jan 1;202:918-21. doi: 10.1016/j.ijcard.2015.09.114. Epub 2015 Oct 22. Link to article on publisher's site

    DOI
    10.1016/j.ijcard.2015.09.114
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30549
    PubMed ID
    26479959
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    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijcard.2015.09.114
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