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dc.contributor.authorZacharias, Michael
dc.contributor.authorJoffe, Samuel
dc.contributor.authorKonadu, Elizabeth
dc.contributor.authorMeyer, Theo E.
dc.contributor.authorKiernan, MIchael S.
dc.contributor.authorLessard, Darleen M.
dc.contributor.authorGoldberg, Robert J.
dc.date2022-08-11T08:08:33.000
dc.date.accessioned2022-08-23T15:58:56Z
dc.date.available2022-08-23T15:58:56Z
dc.date.issued2016-01-01
dc.date.submitted2016-01-07
dc.identifier.citation<p>Int J Cardiol. 2016 Jan 1;202:918-21. doi: 10.1016/j.ijcard.2015.09.114. Epub 2015 Oct 22. <a href="http://dx.doi.org/10.1016/j.ijcard.2015.09.114">Link to article on publisher's site</a></p>
dc.identifier.issn0167-5273 (Linking)
dc.identifier.doi10.1016/j.ijcard.2015.09.114
dc.identifier.pmid26479959
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30549
dc.description.abstractBACKGROUND: While heart failure with preserved ejection fraction (HFpEF) is primarily a disease of old age, risk factors that contribute to HFpEF are not limited to older patients. The objectives of this population-based observational study were to describe the clinical epidemiology of HFpEF in younger ( < 65years) as compared with older ( > /=65years) patients hospitalized with acute decompensated heart failure. METHODS AND RESULTS: We reviewed the medical records of residents of central Massachusetts hospitalized with HFpEF at all 11 greater Worcester (MA) medical centers during the 5 study years of 1995, 2000, 2002, 2004, and 2006. Among the 2398 patients hospitalized with confirmed HFpEF, 357 (14.9%) were < 65years old. Younger patients were more likely to be male, non-Caucasian, obese, and to have a history of diabetes and chronic kidney disease than older patients with HFpEF. Younger patients hospitalized with HFpEF were less likely to have received commonly prescribed cardiac medications, had a longer hospital stay, and experienced significantly lower post-discharge death rates than older hospitalized patients. CONCLUSION: While HFpEF is predominantly a disease of old age, data from longitudinal studies remain needed to identify risk factors in younger individuals that may predispose them to the development of HFpEF.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26479959&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656064/
dc.subjectUMCCTS funding
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectClinical Epidemiology
dc.titleClinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients
dc.typeJournal Article
dc.source.journaltitleInternational journal of cardiology
dc.source.volume202
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/825
dc.identifier.contextkey7992964
html.description.abstract<p>BACKGROUND: While heart failure with preserved ejection fraction (HFpEF) is primarily a disease of old age, risk factors that contribute to HFpEF are not limited to older patients. The objectives of this population-based observational study were to describe the clinical epidemiology of HFpEF in younger ( < 65years) as compared with older ( > /=65years) patients hospitalized with acute decompensated heart failure.</p> <p>METHODS AND RESULTS: We reviewed the medical records of residents of central Massachusetts hospitalized with HFpEF at all 11 greater Worcester (MA) medical centers during the 5 study years of 1995, 2000, 2002, 2004, and 2006. Among the 2398 patients hospitalized with confirmed HFpEF, 357 (14.9%) were < 65years old. Younger patients were more likely to be male, non-Caucasian, obese, and to have a history of diabetes and chronic kidney disease than older patients with HFpEF. Younger patients hospitalized with HFpEF were less likely to have received commonly prescribed cardiac medications, had a longer hospital stay, and experienced significantly lower post-discharge death rates than older hospitalized patients.</p> <p>CONCLUSION: While HFpEF is predominantly a disease of old age, data from longitudinal studies remain needed to identify risk factors in younger individuals that may predispose them to the development of HFpEF.</p>
dc.identifier.submissionpathfaculty_pubs/825
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages918-21


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