Depression and quality of life before and after breast cancer diagnosis in older women from the Women's Health Initiative
dc.contributor.author | Jones, Salene M.W. | |
dc.contributor.author | LaCroix, Andrea Z. | |
dc.contributor.author | Li, Wenjun | |
dc.contributor.author | Zaslavsky, Oleg | |
dc.contributor.author | Wassertheil-Smoller, Sylvia | |
dc.contributor.author | Weitlauf, Julie | |
dc.contributor.author | Brenes, Gretchen A. | |
dc.contributor.author | Nassir, Rami | |
dc.contributor.author | Ockene, Judith K. | |
dc.contributor.author | Caire-Juvera, Graciela | |
dc.contributor.author | Danhauer, Suzanne C. | |
dc.date | 2022-08-11T08:08:33.000 | |
dc.date.accessioned | 2022-08-23T15:59:00Z | |
dc.date.available | 2022-08-23T15:59:00Z | |
dc.date.issued | 2015-12-01 | |
dc.date.submitted | 2016-01-07 | |
dc.identifier.citation | J Cancer Surviv. 2015 Dec;9(4):620-9. doi: 10.1007/s11764-015-0438-y. Epub 2015 Feb 24. <a href="http://dx.doi.org/10.1007/s11764-015-0438-y">Link to article on publisher's site</a> | |
dc.identifier.issn | 1932-2259 (Linking) | |
dc.identifier.doi | 10.1007/s11764-015-0438-y | |
dc.identifier.pmid | 25708515 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/30562 | |
dc.description.abstract | PURPOSE: Distress and reduced quality of life (QOL) are common among people with cancer. No study has compared these variables after breast cancer diagnosis to pre-cancer diagnosis levels. METHODS: Data on women with breast cancer 50 years of age or older (n = 6949) were analyzed from the Women's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. Depressive symptoms were measured with the six-item Center for Epidemiologic Studies Depression scale. Assessments occurred before and after the cancer diagnosis. Hierarchical linear modeling compared pre-cancer QOL and depressive symptoms to levels post-diagnosis and tested whether pre-cancer physical activity, stressful life events, sleep disturbance, and pain predicted post-diagnosis outcomes. RESULTS: Compared with pre-cancer levels, depressive symptoms increased (20.0 % increase at 0-6 months, 12.9 % increase at 6-12 months), while physical function (-3.882 points at 0-6 months, -3.545 at 6-12 months) and mental health decreased (-2.899 points at 0-6 months, -1.672 at 6-12 months) in the first year after diagnosis (all p < .01). Depressive symptoms returned to pre-cancer levels after 10 years, but QOL remained significantly lower. At more than 10 years post-diagnosis, physical function was 2.379 points lower than pre-cancer levels (p < 0.01) while mental health was 1.922 points lower (p < 0.01). All pre-cancer predictors were associated with all outcomes. Pain predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: Depressive symptoms increased and QOL decreased following breast cancer diagnosis compared with pre-cancer levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after breast cancer diagnosis, although decreases are small. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25708515&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1007/s11764-015-0438-y | |
dc.subject | Breast cancer | |
dc.subject | Depression | |
dc.subject | Distress | |
dc.subject | Health-related quality of life | |
dc.subject | Neoplasm | |
dc.subject | Women’s health | |
dc.subject | Mental and Social Health | |
dc.subject | Neoplasms | |
dc.subject | Psychiatry and Psychology | |
dc.subject | Women's Health | |
dc.title | Depression and quality of life before and after breast cancer diagnosis in older women from the Women's Health Initiative | |
dc.type | Journal Article | |
dc.source.journaltitle | Journal of cancer survivorship : research and practice | |
dc.source.volume | 9 | |
dc.source.issue | 4 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/839 | |
dc.identifier.contextkey | 7992979 | |
html.description.abstract | <p>PURPOSE: Distress and reduced quality of life (QOL) are common among people with cancer. No study has compared these variables after breast cancer diagnosis to pre-cancer diagnosis levels.</p> <p>METHODS: Data on women with breast cancer 50 years of age or older (n = 6949) were analyzed from the Women's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. Depressive symptoms were measured with the six-item Center for Epidemiologic Studies Depression scale. Assessments occurred before and after the cancer diagnosis. Hierarchical linear modeling compared pre-cancer QOL and depressive symptoms to levels post-diagnosis and tested whether pre-cancer physical activity, stressful life events, sleep disturbance, and pain predicted post-diagnosis outcomes.</p> <p>RESULTS: Compared with pre-cancer levels, depressive symptoms increased (20.0 % increase at 0-6 months, 12.9 % increase at 6-12 months), while physical function (-3.882 points at 0-6 months, -3.545 at 6-12 months) and mental health decreased (-2.899 points at 0-6 months, -1.672 at 6-12 months) in the first year after diagnosis (all p < .01). Depressive symptoms returned to pre-cancer levels after 10 years, but QOL remained significantly lower. At more than 10 years post-diagnosis, physical function was 2.379 points lower than pre-cancer levels (p < 0.01) while mental health was 1.922 points lower (p < 0.01). All pre-cancer predictors were associated with all outcomes. Pain predicted uniquely greater decreases in physical function post-diagnosis.</p> <p>CONCLUSIONS: Depressive symptoms increased and QOL decreased following breast cancer diagnosis compared with pre-cancer levels, particularly in the first year.</p> <p>IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after breast cancer diagnosis, although decreases are small.</p> | |
dc.identifier.submissionpath | faculty_pubs/839 | |
dc.contributor.department | Prevention Research Center | |
dc.contributor.department | Department of Medicine, Division of Preventive and Behavioral Medicine | |
dc.source.pages | 620-9 |