Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyProgram in Innate Immunity
Document Type
Journal ArticlePublication Date
2016-01-14
Metadata
Show full item recordAbstract
An important concept in immunology is the classification of immune responses as either innate or adaptive, based on whether the antigen receptors are encoded in the germline or generated somatically by gene rearrangement. The innate immune system is an ancient mode of immunity, and by being a first layer in our defense against infectious agents, it is essential for our ability to develop rapid and sustained responses to pathogens. We discuss the importance of nucleic acid recognition by the innate immune system to mounting an appropriate immune response to pathogens and also how inflammation driven by uncontrolled recognition of self-nucleic acids can lead to autoimmune diseases. We also summarize current efforts to either harness the immune system using agonists of nucleic acid-specific innate sensors or, on the contrary, by using inhibitors in autoimmune situations.Source
Annu Rev Med. 2016 Jan 14;67:323-36. doi: 10.1146/annurev-med-052814-023338. Epub 2015 Nov 2. Link to article on publisher's siteDOI
10.1146/annurev-med-052814-023338Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30593PubMed ID
26526766Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1146/annurev-med-052814-023338