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    Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity

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    Authors
    Barrat, Franck J.
    Elkon, Keith B.
    Fitzgerald, Katherine A.
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Program in Innate Immunity
    Document Type
    Journal Article
    Publication Date
    2016-01-14
    Keywords
    autoimmunity
    innate immunity
    nucleic acids
    pattern recognition receptors
    therapeutics
    Immunity
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1146/annurev-med-052814-023338
    Abstract
    An important concept in immunology is the classification of immune responses as either innate or adaptive, based on whether the antigen receptors are encoded in the germline or generated somatically by gene rearrangement. The innate immune system is an ancient mode of immunity, and by being a first layer in our defense against infectious agents, it is essential for our ability to develop rapid and sustained responses to pathogens. We discuss the importance of nucleic acid recognition by the innate immune system to mounting an appropriate immune response to pathogens and also how inflammation driven by uncontrolled recognition of self-nucleic acids can lead to autoimmune diseases. We also summarize current efforts to either harness the immune system using agonists of nucleic acid-specific innate sensors or, on the contrary, by using inhibitors in autoimmune situations.
    Source
    Annu Rev Med. 2016 Jan 14;67:323-36. doi: 10.1146/annurev-med-052814-023338. Epub 2015 Nov 2. Link to article on publisher's site
    DOI
    10.1146/annurev-med-052814-023338
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30593
    PubMed ID
    26526766
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1146/annurev-med-052814-023338
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