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dc.contributor.authorChang, Milan
dc.contributor.authorSnaedal, Jon
dc.contributor.authorEinarsson, Bjorn
dc.contributor.authorBjornsson, Sigurbjorn
dc.contributor.authorSaczynski, Jane S.
dc.contributor.authorAspelund, Thor
dc.contributor.authorGarcia, Melissa
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorJonsson, Palmi V.
dc.date2022-08-11T08:08:33.000
dc.date.accessioned2022-08-23T15:59:08Z
dc.date.available2022-08-23T15:59:08Z
dc.date.issued2015-11-02
dc.date.submitted2016-02-24
dc.identifier.citationJ Gerontol A Biol Sci Med Sci. 2015 Nov 2. pii: glv196. <a href="http://dx.doi.org/10.1093/gerona/glv196">Link to article on publisher's site</a>
dc.identifier.issn1079-5006 (Linking)
dc.identifier.doi10.1093/gerona/glv196
dc.identifier.pmid26525090
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30595
dc.description.abstractBACKGROUND: There is little evidence on the long-term association between physical activity (PA) and depressive symptoms in old age. We examined the association of midlife PA and depressive symptoms in late life. METHODS: A large community-based population residing in Reykjavik, Iceland, participated in a longitudinal study with an average of 25 years of follow up. Midlife PA was categorized as active and inactive groups (n = 4,140, Active = 1,292, Inactive = 2,848, mean age 52+/-7 years). The main outcome had six or higher depressive symptoms assessed by the 15-item Geriatric Depression scale. Participants who had a history of depression (n = 226), and were diagnosed with dementia (n = 393), and had incomplete cognitive data (n = 595) and incomplete analytical data (n = 422) were excluded. Level of weekly PA was ascertained by a questionnaire at midlife. Depressive symptoms were assessed on average 25 (+/-4) years later. RESULTS: After controlling for demographic and health-related risk factors, those who were active at midlife were less likely to have high level of depressive symptomatology (6 or higher Geriatric Depression scale scores, odds ratio = 0.58, 95% confidence interval: 0.41-0.83, p < .005) compared with those who were inactive in midlife. After full adjustment of three domains of late-life cognitive function the results remained significant (odds ratio = 0.61, 95% confidence interval: 0.43-0.86, p = .005). CONCLUSION: Our study shows that midlife PA is associated with lower depressive symptoms 25 years later. Participating in regular PA in midlife may improve mental health in late life.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26525090&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1093/gerona/glv196
dc.subjectAging
dc.subjectCognitive function.
dc.subjectDepressive symptomatology
dc.subjectMid-life physical activity
dc.subjectBehavior and Behavior Mechanisms
dc.subjectGeriatrics
dc.subjectMental Disorders
dc.titleThe Association Between Midlife Physical Activity and Depressive Symptoms in Late Life: Age Gene/Environment Susceptibility-Reykjavik Study
dc.typeJournal Article
dc.source.journaltitleThe journals of gerontology. Series A, Biological sciences and medical sciences
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/874
dc.identifier.contextkey8205603
html.description.abstract<p>BACKGROUND: There is little evidence on the long-term association between physical activity (PA) and depressive symptoms in old age. We examined the association of midlife PA and depressive symptoms in late life.</p> <p>METHODS: A large community-based population residing in Reykjavik, Iceland, participated in a longitudinal study with an average of 25 years of follow up. Midlife PA was categorized as active and inactive groups (n = 4,140, Active = 1,292, Inactive = 2,848, mean age 52+/-7 years). The main outcome had six or higher depressive symptoms assessed by the 15-item Geriatric Depression scale. Participants who had a history of depression (n = 226), and were diagnosed with dementia (n = 393), and had incomplete cognitive data (n = 595) and incomplete analytical data (n = 422) were excluded. Level of weekly PA was ascertained by a questionnaire at midlife. Depressive symptoms were assessed on average 25 (+/-4) years later.</p> <p>RESULTS: After controlling for demographic and health-related risk factors, those who were active at midlife were less likely to have high level of depressive symptomatology (6 or higher Geriatric Depression scale scores, odds ratio = 0.58, 95% confidence interval: 0.41-0.83, p < .005) compared with those who were inactive in midlife. After full adjustment of three domains of late-life cognitive function the results remained significant (odds ratio = 0.61, 95% confidence interval: 0.43-0.86, p = .005).</p> <p>CONCLUSION: Our study shows that midlife PA is associated with lower depressive symptoms 25 years later. Participating in regular PA in midlife may improve mental health in late life.</p>
dc.identifier.submissionpathfaculty_pubs/874
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDepartment of Medicine, Division of Geriatric Medicine


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