The Association Between Midlife Physical Activity and Depressive Symptoms in Late Life: Age Gene/Environment Susceptibility-Reykjavik Study
dc.contributor.author | Chang, Milan | |
dc.contributor.author | Snaedal, Jon | |
dc.contributor.author | Einarsson, Bjorn | |
dc.contributor.author | Bjornsson, Sigurbjorn | |
dc.contributor.author | Saczynski, Jane S. | |
dc.contributor.author | Aspelund, Thor | |
dc.contributor.author | Garcia, Melissa | |
dc.contributor.author | Gudnason, Vilmundur | |
dc.contributor.author | Harris, Tamara B. | |
dc.contributor.author | Launer, Lenore J. | |
dc.contributor.author | Jonsson, Palmi V. | |
dc.date | 2022-08-11T08:08:33.000 | |
dc.date.accessioned | 2022-08-23T15:59:08Z | |
dc.date.available | 2022-08-23T15:59:08Z | |
dc.date.issued | 2015-11-02 | |
dc.date.submitted | 2016-02-24 | |
dc.identifier.citation | J Gerontol A Biol Sci Med Sci. 2015 Nov 2. pii: glv196. <a href="http://dx.doi.org/10.1093/gerona/glv196">Link to article on publisher's site</a> | |
dc.identifier.issn | 1079-5006 (Linking) | |
dc.identifier.doi | 10.1093/gerona/glv196 | |
dc.identifier.pmid | 26525090 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/30595 | |
dc.description.abstract | BACKGROUND: There is little evidence on the long-term association between physical activity (PA) and depressive symptoms in old age. We examined the association of midlife PA and depressive symptoms in late life. METHODS: A large community-based population residing in Reykjavik, Iceland, participated in a longitudinal study with an average of 25 years of follow up. Midlife PA was categorized as active and inactive groups (n = 4,140, Active = 1,292, Inactive = 2,848, mean age 52+/-7 years). The main outcome had six or higher depressive symptoms assessed by the 15-item Geriatric Depression scale. Participants who had a history of depression (n = 226), and were diagnosed with dementia (n = 393), and had incomplete cognitive data (n = 595) and incomplete analytical data (n = 422) were excluded. Level of weekly PA was ascertained by a questionnaire at midlife. Depressive symptoms were assessed on average 25 (+/-4) years later. RESULTS: After controlling for demographic and health-related risk factors, those who were active at midlife were less likely to have high level of depressive symptomatology (6 or higher Geriatric Depression scale scores, odds ratio = 0.58, 95% confidence interval: 0.41-0.83, p < .005) compared with those who were inactive in midlife. After full adjustment of three domains of late-life cognitive function the results remained significant (odds ratio = 0.61, 95% confidence interval: 0.43-0.86, p = .005). CONCLUSION: Our study shows that midlife PA is associated with lower depressive symptoms 25 years later. Participating in regular PA in midlife may improve mental health in late life. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26525090&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1093/gerona/glv196 | |
dc.subject | Aging | |
dc.subject | Cognitive function. | |
dc.subject | Depressive symptomatology | |
dc.subject | Mid-life physical activity | |
dc.subject | Behavior and Behavior Mechanisms | |
dc.subject | Geriatrics | |
dc.subject | Mental Disorders | |
dc.title | The Association Between Midlife Physical Activity and Depressive Symptoms in Late Life: Age Gene/Environment Susceptibility-Reykjavik Study | |
dc.type | Journal Article | |
dc.source.journaltitle | The journals of gerontology. Series A, Biological sciences and medical sciences | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/874 | |
dc.identifier.contextkey | 8205603 | |
html.description.abstract | <p>BACKGROUND: There is little evidence on the long-term association between physical activity (PA) and depressive symptoms in old age. We examined the association of midlife PA and depressive symptoms in late life.</p> <p>METHODS: A large community-based population residing in Reykjavik, Iceland, participated in a longitudinal study with an average of 25 years of follow up. Midlife PA was categorized as active and inactive groups (n = 4,140, Active = 1,292, Inactive = 2,848, mean age 52+/-7 years). The main outcome had six or higher depressive symptoms assessed by the 15-item Geriatric Depression scale. Participants who had a history of depression (n = 226), and were diagnosed with dementia (n = 393), and had incomplete cognitive data (n = 595) and incomplete analytical data (n = 422) were excluded. Level of weekly PA was ascertained by a questionnaire at midlife. Depressive symptoms were assessed on average 25 (+/-4) years later.</p> <p>RESULTS: After controlling for demographic and health-related risk factors, those who were active at midlife were less likely to have high level of depressive symptomatology (6 or higher Geriatric Depression scale scores, odds ratio = 0.58, 95% confidence interval: 0.41-0.83, p < .005) compared with those who were inactive in midlife. After full adjustment of three domains of late-life cognitive function the results remained significant (odds ratio = 0.61, 95% confidence interval: 0.43-0.86, p = .005).</p> <p>CONCLUSION: Our study shows that midlife PA is associated with lower depressive symptoms 25 years later. Participating in regular PA in midlife may improve mental health in late life.</p> | |
dc.identifier.submissionpath | faculty_pubs/874 | |
dc.contributor.department | Meyers Primary Care Institute | |
dc.contributor.department | Department of Medicine, Division of Geriatric Medicine |