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    Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses

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    Authors
    Huang, Wei
    Tam, Kelly
    Fernando, Janaque
    Heffernan, Meghan E.
    King, Jean A.
    DiFranza, Joseph R.
    UMass Chan Affiliations
    Department of Family Medicine and Community Health
    Department of Psychiatry, Center for Comparative NeuroImaging
    Document Type
    Journal Article
    Publication Date
    2015-11-01
    Keywords
    Neuroscience and Neurobiology
    Psychiatry
    Psychiatry and Psychology
    Substance Abuse and Addiction
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1093/ntr/ntv009
    Abstract
    INTRODUCTION: It is unknown how the timing between doses might affect nicotine's impact on neural activity. Our objective was to examine how the interdose interval affects nicotine's impact on resting-state functional connectivity (rsFC). MATERIALS AND METHODS: Adult male Sprague-Dawley rats were administered nicotine daily (0.4 mg/kg) over 6 days while control animals received saline vehicle. Functional magnetic resonance imaging was used to measure rsFC before and after a challenge dose of nicotine (0.4 mg/kg) delivered for the first time and 3, 6, 12, or 24hr after the previous dose. RESULTS: As the interval between nicotine doses increased from 3 to 24hr, the strength of rsFC increased in some circuits, particularly the nucleus accumbens and prefrontal circuits, and decreased in others, namely the interpeduncular nucleus, hippocampus, caudoputamen, retrosplenial cortex, ventral tegmental, and the insular circuits. CONCLUSIONS: These data indicate that the effect that nicotine has on the brain is affected by the amount of time that has passed since the previous dose. The effect on rsFC of cumulative doses is not additive. This may have important implications for the study of nicotine addiction as it implies that the same dose of nicotine might have a different impact on the brain depending on the time elapsed from the previous exposure.
    Source
    Nicotine Tob Res. 2015 Nov;17(11):1311-7. doi: 10.1093/ntr/ntv009. Epub 2015 Feb 2. Link to article on publisher's site
    DOI
    10.1093/ntr/ntv009
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30609
    PubMed ID
    25646348
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/ntr/ntv009
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