Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds(R) Consensus Exercises
Authors
de Lautour, HughTaylor, William J.
Adebajo, Ade
Alten, Rieke
Burgos-Vargas, Ruben
Chapman, Peter
Cimmino, Marco A.
da Rocha Castelar Pinheiro, Geraldo
Day, Ric
Harrold, Leslie R.
Helliwell, Philip
Janssen, Matthijs
Kerr, Gail
Kavanaugh, Arthur
Khanna, Dinesh
Khanna, Puja P.
Lin, Chingtsai
Louthrenoo, Worawit
McCarthy, Geraldine
Vazquez-Mellado, Janitzia
Mikuls, Ted R.
Neogi, Tuhina
Ogdie, Alexis
Perez-Ruiz, Fernando
Schlesinger, Naomi
Schumacher, H. Ralph
Scire, Carlo A.
Singh, Jasvinder A.
Sivera, Francisca
Slot, Ole
Stamp, Lisa K.
Tausche, Anne-Kathrin
Terkeltaub, Robert
Uhlig, Till
van de Laar, Mart
White, Douglas
Yamanaka, Hisashi
Zeng, Xuejun
Dalbeth, Nicola
UMass Chan Affiliations
Meyers Primary Care InstituteDepartment of Orthopedics and Physical Rehabilitation
Document Type
Journal ArticlePublication Date
2016-05-01
Metadata
Show full item recordAbstract
OBJECTIVES: The aim of this study was to establish consensus for potential remission criteria for use in clinical trials of gout. METHODS: Experts (n=88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey(R) followed by a discrete choice experiment using 1000Minds(R). The exercises focused on identifying domains, definitions for each domain and the timeframe over which remission should be defined. RESULTS: There were 49 respondents (56% response) to the initial survey with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%) and patient global assessment (93%) of disease activity as measurement domains in remission criteria. Consensus was also reached for domain definitions including serum urate ( < 0.36mM), pain ( < 2 on a 10-point scale) and patient global assessment ( < 2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission with equal responses for six months (51%) and one year (49%). In the discrete choice experiment, there was a preference towards 12 months as a timeframe for remission. CONCLUSION: These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain and patient global assessment. These preliminary criteria now require testing in clinical datasets.Source
Arthritis Care Res (Hoboken). 2016 May;68(5):667-72. doi: 10.1002/acr.22741. Link to article on publisher's siteDOI
10.1002/acr.22741Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30646PubMed ID
26414176Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/acr.22741