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    Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts

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    Authors
    Baum, Rebecca
    Gravallese, Ellen M.
    UMass Chan Affiliations
    Department of Medicine, Division of Rheumatology
    Document Type
    Journal Article
    Publication Date
    2015-09-28
    Keywords
    Ankylosing spondylitis
    Bone erosions
    Bone formation
    Bone remodeling
    DKK1
    Entheses
    IL-23
    Inflammation
    Osteoblast
    Osteoclast
    Rheumatoid arthritis
    Sclerostin
    Wnt
    microRNAs
    Allergy and Immunology
    Cell Biology
    Musculoskeletal Diseases
    Rheumatology
    Skin and Connective Tissue Diseases
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    Link to Full Text
    http://dx.doi.org/10.1007/s12016-015-8515-6
    Abstract
    Dysregulated bone remodeling occurs when there is an imbalance between bone resorption and bone formation. In rheumatic diseases, including rheumatoid arthritis (RA) and seronegative spondyloarthritis, systemic and local factors disrupt the process of physiologic bone remodeling. Depending upon the local microenvironment, cell types, and local mechanical forces, inflammation results in very different effects on bone, promoting bone loss in the joints and in periarticular and systemic bone in RA and driving bone formation at enthesial and periosteal sites in diseases such as ankylosing spondylitis (AS), included within the classification of axial spondyloarthritis. There has been a great deal of interest in the role of osteoclasts in these processes and much has been learned over the past decade about osteoclast differentiation and function. It is now appreciated that osteoblast-mediated bone formation is also inhibited in the RA joint, limiting the repair of erosions. In contrast, osteoblasts function to produce new bone in AS. The Wnt and BMP signaling pathways have emerged as critical in the regulation of osteoblast function and the outcome for bone in rheumatic diseases, and these pathways have been implicated in both bone loss in RA and bone formation in AS. These pathways provide potential novel approaches for therapeutic intervention in diseases in which inflammation impacts bone.
    Source
    Clin Rev Allergy Immunol. 2015 Sep 28. Link to article on publisher's site
    DOI
    10.1007/s12016-015-8515-6
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30647
    PubMed ID
    26411424
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12016-015-8515-6
    Scopus Count
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