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dc.contributor.authorVejbaesya, Sasijit
dc.contributor.authorThongpradit, Rungrot
dc.contributor.authorKalayanarooj, Siripen
dc.contributor.authorLuangtrakool, Komon
dc.contributor.authorLuangtrakool, Panpimon
dc.contributor.authorGibbons, Robert V.
dc.contributor.authorSrinak, Duangporn
dc.contributor.authorNgammthaworn, Somporn
dc.contributor.authorApisawes, Kusuma
dc.contributor.authorYoon, In-Kyu
dc.contributor.authorThomas, Stephen J.
dc.contributor.authorJarman, Richard G.
dc.contributor.authorSrikiatkhachorn, Anon
dc.contributor.authorGreen, Sharone
dc.contributor.authorChandanayingyong, Dasnayanee
dc.contributor.authorPark, Sangshin
dc.contributor.authorFriedman, Jennifer
dc.contributor.authorRothman, Alan L.
dc.contributor.authorStephens, Henry A.F.
dc.date2022-08-11T08:08:34.000
dc.date.accessioned2022-08-23T15:59:23Z
dc.date.available2022-08-23T15:59:23Z
dc.date.issued2015-09-15
dc.date.submitted2016-03-23
dc.identifier.citationJ Infect Dis. 2015 Sep 15;212(6):939-47. doi: 10.1093/infdis/jiv127. Epub 2015 Mar 4. <a href="http://dx.doi.org/10.1093/infdis/jiv127">Link to article on publisher's site</a>
dc.identifier.issn0022-1899 (Linking)
dc.identifier.doi10.1093/infdis/jiv127
dc.identifier.pmid25740956
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30654
dc.description.abstractBACKGROUND: Human leukocyte antigen (HLA) supertypes are groups of functionally related alleles that present structurally similar antigens to the immune system. OBJECTIVES: To analyze HLA class I supertype associations with clinical outcome in hospitalized Thai children with acute dengue illness. METHODS: Seven hundred sixty-two patients and population-matched controls recruited predominantly in Bangkok were HLA-A and -B typed. HLA supertype frequencies were compared and tested for significant dengue disease associations using logistic regression analyses. Multivariable models were built by conducting forward stepwise selection procedures. RESULTS: In the final logistic regression model, the HLA-B44 supertype was protective against dengue hemorrhagic fever (DHF) in secondary infections (odds ratio [OR] = 0.46, 95% confidence interval [CI], .30-.72), while the HLA-A02 supertype (OR = 1.92, 95% CI, 1.30-2.83) and the HLA-A01/03 supertype (OR = 3.01, 95% CI, 1.01-8.92) were associated with susceptibility to secondary dengue fever. The B07 supertype was associated with susceptibility to secondary DHF in the univariate analysis (OR = 1.60, 95% CI, 1.05-2.46), whereas that was not retained in the final model. CONCLUSIONS: As the HLA-B44 supertype is predicted to target conserved epitopes in dengue, our results suggest that B44 supertype-restricted immune responses to highly conserved regions of the dengue proteome may protect against secondary DHF.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25740956&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1093/infdis/jiv127
dc.subjectAdolescent
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCohort Studies
dc.subject*Dengue Virus
dc.subject*Ethnic Groups
dc.subjectGenes, MHC Class I
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectLogistic Models
dc.subjectMultivariate Analysis
dc.subjectOdds Ratio
dc.subjectSevere Dengue
dc.subjectThailand
dc.subjectB44
dc.subjectHLA
dc.subjectThais
dc.subjectassociations
dc.subjectclass I
dc.subjectdengue
dc.subjectinfections
dc.subjectsecondary
dc.subjectsupertype
dc.subjectImmunology of Infectious Disease
dc.subjectImmunopathology
dc.subjectInfectious Disease
dc.subjectVirus Diseases
dc.titleHLA Class I Supertype Associations With Clinical Outcome of Secondary Dengue Virus Infections in Ethnic Thais
dc.typeJournal Article
dc.source.journaltitleThe Journal of infectious diseases
dc.source.volume212
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/931
dc.identifier.contextkey8371023
html.description.abstract<p>BACKGROUND: Human leukocyte antigen (HLA) supertypes are groups of functionally related alleles that present structurally similar antigens to the immune system.</p> <p>OBJECTIVES: To analyze HLA class I supertype associations with clinical outcome in hospitalized Thai children with acute dengue illness.</p> <p>METHODS: Seven hundred sixty-two patients and population-matched controls recruited predominantly in Bangkok were HLA-A and -B typed. HLA supertype frequencies were compared and tested for significant dengue disease associations using logistic regression analyses. Multivariable models were built by conducting forward stepwise selection procedures.</p> <p>RESULTS: In the final logistic regression model, the HLA-B44 supertype was protective against dengue hemorrhagic fever (DHF) in secondary infections (odds ratio [OR] = 0.46, 95% confidence interval [CI], .30-.72), while the HLA-A02 supertype (OR = 1.92, 95% CI, 1.30-2.83) and the HLA-A01/03 supertype (OR = 3.01, 95% CI, 1.01-8.92) were associated with susceptibility to secondary dengue fever. The B07 supertype was associated with susceptibility to secondary DHF in the univariate analysis (OR = 1.60, 95% CI, 1.05-2.46), whereas that was not retained in the final model.</p> <p>CONCLUSIONS: As the HLA-B44 supertype is predicted to target conserved epitopes in dengue, our results suggest that B44 supertype-restricted immune responses to highly conserved regions of the dengue proteome may protect against secondary DHF.</p>
dc.identifier.submissionpathfaculty_pubs/931
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages939-47


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