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    Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis

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    Authors
    Szabo, Gyongyi
    Iracheta-Vellve, Arvin
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences
    Department of Medicine, Division of Gastroenterology
    Document Type
    Journal Article
    Publication Date
    2015-09-01
    Keywords
    Digestive System Diseases
    Gastroenterology
    Hepatology
    Immunity
    Immunopathology
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.clinre.2015.06.012
    Abstract
    Upregulation of the inflammatory cascade is a major element both in the progression of steatohepatitis to severe alcoholic hepatitis as well as in the progression of NASH to advanced NASH with fibrosis. The mechanisms underpinning these changes are only partially understood. Activation of the inflammatory cascade requires multiple stimuli and in this report, we discuss the role of inflammasomes that activate IL-1beta as well as the sterile and pathogen-derived danger signals that results in inflammasome activation and inflammation in alcoholic and non-alcoholic steatohepatitis. The dynamics of inflammasome activation, the cell types involved and the trigger signals appear to be somewhat different between ASH and NASH. Further studies are needed to dissect the pathology-related differences between these two major forms of steatohepatitis. Clinical and therapeutic implications of inflammasome activation in steatohepatitis are also discussed.
    Source
    Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S18-23. doi: 10.1016/j.clinre.2015.06.012. Epub 2015 Jul 26. Link to article on publisher's site
    DOI
    10.1016/j.clinre.2015.06.012
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30660
    PubMed ID
    26216030
    Notes

    Co-author Arvin Iracheta-Vellve is a doctoral student in the Translational Science Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

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    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clinre.2015.06.012
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